EC - T-plasminogen activator

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IntEnz Enzyme Nomenclature


Accepted name:
t-plasminogen activator
Other names:
plasminogen activator, tissue-type
tissue plasminogen activator
tissue-type plasminogen activator
Systematic name:



A peptidase of family S1 (trypsin family) from a wide variety of mammalian tissues, especially endothelial cells. Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin. Activity is considerably enhanced by fibrin. Formerly included in EC and EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008243
CAS Registry Number: 139639-23-9 (not distinguished from EC
UniProtKB/Swiss-Prot: (10) [show] [UniProt]


  1. Pennica, D., Holmes, W.E., Kohr, W.J., Harkins, R.N., Vehar, G.A., Ward, C.A., Bennett, W.F., Yelverton, E., Seeburg, P.H., Heyneker, H.L., Goeddel, D.V. and Collen, D.
    Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli.
    Nature 301: 214-221 (1983). [PMID: 6337343]
  2. Loskutoff, D.J. and Schleef, R.R.
    Plasminogen activators and their inhibitors.
    Methods Enzymol. 163: 293-302 (1988). [PMID: 3148826]
  3. Petersen, L.C., Johannessen, M., Forster, D., Kumar, A. and Mulvihill, E.
    The effect of polymerised fibrin on the catalytic activities of one-chain tissue-type plasminogen activator as revealed by an analogue resistant to plasmin cleavage.
    Biochim. Biophys. Acta 952: 245-254 (1988). [PMID: 2962643]
  4. Verheijen, J.H.
    Tissue-type plasminogen activator and fast-acting plasminogen activator inhibitor in plasma.
    Methods Enzymol. 163: 302-309 (1988). [PMID: 3148827]
  5. Gerard, R.D. and Meidell, R.S.
    Regulation of tissue plasminogen activator expression.
    Annu. Rev. Physiol. 51: 245-262 (1989). [PMID: 2496643]
  6. Collen, D., Lijnen, H. R. and Verstraete, M.
    The fibrinolytic system and its disorders.
    In: Handin, R.I., Lux, S.E. and Stossel, J.P. (Eds.) Blood: Principles and Practice of Hematology, 2nd ed., J.B. Lippincott Company, Philadelphia, 1990

[EC created 1972 as EC, transferred 1978 as EC, part transferred 1992 to EC]