EC - Peptidase K

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IntEnz Enzyme Nomenclature


Accepted name:
peptidase K
Other names:
Tritirachium album proteinase K
Tritirachium album serine proteinase
Tritirachium alkaline proteinase
proteinase K
endopeptidase K
Systematic name:



From the mold Tritirachium album Limber. A peptidase of family S8 (subtilisin family) containing two disulfide bridges and one free Cys near the active site His. Formerly included in EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00125
Structural data: CSA , EC2PDB
CAS Registry Number: 39450-01-6


  1. Ebeling, W., Hennrich, N., Klockow, M., Metz, H., Orth, H.D. and Lang, H.
    Proteinase K from Tritirachium album Limber.
    Eur. J. Biochem. 47: 91-97 (1974). [PMID: 4373242]
  2. Morihara, K. and Tsuzuki, H.
    Specificity of proteinase K from Tritirachium album Limber for synthetic peptides.
    Agric. Biol. Chem. 39: 1489-1492 (1975).
  3. Kraus, E., Klitz, H.H. and Fembert, U.F.
    The specificity of proteinase K against oxidized insulin B chain.
    Hoppe-Seyler's Z. Physiol. Chem. 357: 233-237 (1976). [PMID: 943367]
  4. Jany, K.-D., Lederer, G. and Mayer, B.
    Amino acid sequence of proteinase K from the mold Tritirachium album Limber.
    FEBS Lett. 199: 139-144 (1986).
  5. Betzel, C., Teplyakov, A.V., Harutyunyan, E.H., Saenger, W. and Wilson, K.S.
    Thermitase and proteinase K: a comparison of the refined three-dimensional structures of the native enzymes.
    Protein Engineering 3: 161-172 (1990). [PMID: 2184432]

[EC created 1992 (EC created 1961 as EC, transferred 1972 to EC, modified 1986, part incorporated 1992)]