EC 3.4.21.60 - Scutelarin

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IntEnz Enzyme Nomenclature
EC 3.4.21.60

Names

Accepted name:
scutelarin
Other names:
Oxyuranus scutellatus prothrombin-activating proteinase
taipan activator
Systematic name:
-

Reaction

Comments:

From the venom of the Taipan snake (Oxyuranus scutellatus). Converts prothrombin to thrombin. Specificity is similar to that of Factor Xa (EC 3.4.21.6). However, unlike Factor Xa this enzyme can cleave its target in the absence of coagulation Factor Va. Activity is potentiated by phospholipid and Ca2+ which binds via γ-carboxyglutamic acid residues. Similar enzymes are known from the venom of other Australian elapid snakes, including Pseudonaja textilis textilis, Oxyuranus microlepidotus and Demansia nuchalis affinis.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB
CAS Registry Number: 93389-45-8

References

  1. Walker, F.J., Owen, W.G. and Esmon, C.T.
    Characterization of the prothrombin activator from the venom of Oxyuranus scutellatus scutellatus (taipan venom).
    Biochemistry 19 : 1020-1023 (1980). [PMID: 6986908]
  2. Speijer, H., Govers-Reimslag, J.W., Zwaal, R.F. and Rosing, J.
    Prothrombin activation by an activator from the venom of Oxyuranus scutellatus (taipan snake).
    J. Biol. Chem. 261 : 13258-13267 (1986). [PMID: 3531198]

[EC 3.4.21.60 created 1978 as EC 3.4.99.28, transferred 1992 to EC 3.4.21.60, modified 2010]