EC - Tryptase

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
lung tryptase
mast cell neutral proteinase
mast cell protease II
mast cell proteinase II
mast cell serine proteinase II
mast cell serine proteinase tryptase
mast cell tryptase
pituitary tryptase
rat mast cell protease II
skin tryptase
tryptase M
Systematic name:



Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. In peptidase family S1 (trypsin family). Not inhibited by α1-proteinase inhibitor or α2-macroglobulin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
Gene Ontology: GO:0030019
CAS Registry Number: 97501-93-4
UniProtKB/Swiss-Prot: (11) [show] [UniProt]


  1. Tanaka, T., McRae, B.J., Cho, K., Cook, R., Fraki, J.E., Johnson, D.A. and Powers, J.C.
    Mammalian tissue trypsin-like enzymes. Comparative reactivities of human skin tryptase, human lung tryptase, and bovine trypsin with peptide 4-nitroanilide and thioester substrates.
    J. Biol. Chem. 258: 13552-13557 (1983). [PMID: 6358206]
  2. Kido, H., Fukusen, N. and Katunuma, N.
    Chymotrypsin- and trypsin-type serine proteases in rat mast cells: properties and functions.
    Arch. Biochem. Biophys. 239: 436-443 (1985). [PMID: 3890754]
  3. Cromlish, J.A., Seidah, N.G., Marcinkiewitz, M., Hamelin, J., Johnson, D.A. and Chrétien, M.
    Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates.
    J. Biol. Chem. 262: 1363-1373 (1987). [PMID: 3543004]
  4. Harvima, I.T., Schechter, N.M., Harvima, R.J. and Fräki, J.E.
    Human skin tryptase: purification, partial characterization and comparison with human lung tryptase.
    Biochim. Biophys. Acta 957: 71-80 (1988). [PMID: 3140898]
  5. Vanderslice, P., Ballinger, S.M., Tam, E.K., Goldstein, S.M., Craik, C.S. and Caughey, G.
    Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.
    Proc. Natl. Acad. Sci. USA 87: 3811-3815 (1990). [PMID: 2187193]

[EC created 1992]