EC - Cerevisin

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
baker's yeast proteinase B
brewer's yeast proteinase
peptidase β
proteinase yscB
yeast proteinase B
Systematic name:



From Saccharomyces cerevisiae (baker's yeast, brewer's yeast). In peptidase family S8 (subtilisin family), but contains a Cys residue near the active site His, and is inhibited by mercurials. Proteinase ycaB is a similar enzyme from the yeast Candida albicans [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00125
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004262
CAS Registry Number: 37288-81-6


  1. Félix, F. and Brouillet, N.
    Purification et propriétés de deux peptidases de levure de brassérie.
    Biochim. Biophys. Acta 122: 127-144 (1966). [PMID: 4961236]
  2. Kominami, E., Hoffschulte, H., Leuschel, L., Maier, K. and Holzer, H.
    The substrate specificity of proteinase B from baker's yeast.
    Biochim. Biophys. Acta. 661: 136-141 (1981). [PMID: 7028121]
  3. Farley, P.C., Shepherd, M.G. and Sullivan, P.A.
    The purification and properties of yeast proteinase B from Candida albicans.
    Biochem. J. 236: 177-184 (1986). [PMID: 3539100]
  4. Moehle, C.M., Tizard, R., Lemmon, S.K., Smart, J. and Jones, E.W.
    Protease B of the lysosome like vacuole of the yeast Saccharomyces cerevisiae is homologous to the subtilisin family of serine proteases.
    Mol. Cell. Biol. 7: 4390-4399 (1987). [PMID: 3325823]

[EC created 1972 as EC, transferred 1981 to EC]