EC - Complement factor D

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IntEnz Enzyme Nomenclature


Accepted name:
complement factor D
Other names:
C3 proactivator convertase
factor D
factor D (complement)
properdin factor D esterase
Systematic name:



A component of the alternative pathway of complement activation. This reaction is analogous to the activation of complement component C2 by complement subcomponent C1̅s̅. In peptidase family S1 (trypsin family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004252
CAS Registry Number: 37213-56-2


  1. Reid, K.B.M., Johnson, D.M.A., Gagnon, J. and Prohaska, R.
    Preparation of human factor D̅ of the alternative pathway of complement.
    Methods Enzymol. 80C : 134-143 (1981). [PMID: 6918766]
  2. Müller-Eberhard, H.J.
    Molecular organization and function of the complement system.
    Annu. Rev. Biochem. 57 : 321-347 (1988). [PMID: 3052276]

[EC created 1981]