EC 188.8.131.52 - Complement factor D
IntEnz Enzyme Nomenclature
factor D (complement)
properdin factor D esterase
- Selective cleavage of ArgLys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.
A component of the alternative pathway of complement activation. This reaction is analogous to the activation of complement component C2 by complement subcomponent C1̅s̅. In peptidase family S1 (trypsin family).
Links to other databases
Preparation of human factor D̅ of the alternative pathway of complement.Methods Enzymol. 80C : 134-143 (1981). [PMID: 6918766]
Molecular organization and function of the complement system.Annu. Rev. Biochem. 57 : 321-347 (1988). [PMID: 3052276]
[EC 184.108.40.206 created 1981]