EC 3.4.21.4 - Trypsin

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IntEnz Enzyme Nomenclature
EC 3.4.21.4

Names

Accepted name:
trypsin
Other names:
α-trypsin
β-trypsin
cocoonase
parenzyme
parenzymol
pseudotrypsin
sperm receptor hydrolase
tripcellim
tryptar
tryptase
trypure
Systematic name:
-

Reaction

Comments:

The single polypeptide chain cattle β-trypsin is formed from trypsinogen by cleavage of one peptide bond. Further peptide bond cleavages produce α and other iso-forms. Isolated as multiple cationic and anionic trypsins [5] from the pancreas of many vertebrates and from lower species including crayfish, insects (cocoonase) and microorganisms (Streptomyces griseus) [3]. Type example of peptidase family S1. Formerly EC 3.4.4.4.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004295
CAS Registry Number: 9002-07-7
UniProtKB/Swiss-Prot: (76) [show] [UniProt]

References

  1. Huber, R. and Bode, W.
    Structural basis of the activation and action of trypsin.
    Acc. Chem. Res. 11: 114-122 (1978).
  2. Walsh, K.A.
    Trypsinogens and trypsins of various species.
    Methods Enzymol. 19: 41-63 (1970).
  3. Read, R.J., Brayer, G.D., Jurásek, L. and James, M.N.G.
    Critical evaluation of comparative model building of Streptomyces griseus trypsin.
    Biochemistry 23: 6570-6575 (1984). [PMID: 6442164]
  4. Fiedler, F.
    Effects of secondary interactions on the kinetics of peptide and peptide ester hydrolysis by tissue kallikrein and trypsin.
    Eur. J. Biochem. 163: 303-312 (1987). [PMID: 3643848]
  5. Fletcher, T.S., Alhadeff, M., Craik, C.S. and Largman, C.
    Isolation and characterization of a cDNA encoding rat cationic trypsinogen.
    Biochemistry 26: 3081-3086 (1987). [PMID: 3607011]
  6. Polgár, L.
    Structure and function of serine proteases.
    In: Neuberger, A. and Brocklehurst, K. (Eds.) New Comprehensive Biochemistry vol. 16, Elsevier, Amsterdam, 1987, 159-200
  7. Tani, T., Kawashima, I., Mita, K. and Takiguchi, Y.
    Nucleotide sequence of the human pancreatic trypsinogen III cDNA.
    Nucleic Acids Res. 18: 1631 (1990). [PMID: 2326201]

[EC 3.4.21.4 created 1961 as EC 3.4.4.4, transferred 1972 to EC 3.4.21.4]