EC - Chymase

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
SK protease
mast cell protease I
mast cell serine proteinase
skeletal muscle protease
skin chymotryptic proteinase
skeletal muscle (SK) protease
Systematic name:



In mast cell granules. In peptidase family S1 (trypsin family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004252
CAS Registry Number: 97501-92-3
UniProtKB/Swiss-Prot: (10) [show] [UniProt]


  1. Woodbury, R.G., Everitt, M. and Neurath, H.
    Mast cell proteases.
    Methods Enzymol. 80C : 588-609 (1981). [PMID: 7043202]
  2. Powers, J.C., Tanaka, T., Harper, J.W., Minematsu, Y., Barker, L., Lincoln, D., Crumley, K.V., Fraki, J.E., Schechter, N.M., Lazarus, G.G., Nakajima, K., Nakashino, K., Neurath, H. and Woodbury, R.G.
    Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors.
    Biochemistry 24 : 2048-2058 (1985). [PMID: 3893542]
  3. Johnson, L.A., Moon, K.E. and Eisenberg, M.
    Purification to homogeneity of the human skin chymotryptic proteinase "chymase".
    Anal. Biochem. 155 : 358-364 (1986). [PMID: 2425663]

[EC created 1981]