EC - Coagulation factor XIa

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IntEnz Enzyme Nomenclature


Accepted name:
coagulation factor XIa
Other names:
activated blood-coagulation factor XI
activated plasma thromboplastin antecedent
blood-coagulation factor XIa
plasma thromboplastin antecedent
Systematic name:



In peptidase family S1 (trypsin family), and one of the γ-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor XI is activated by factor XIIa.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124 , PROSITE:PDOC00376
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003805
CAS Registry Number: 37203-61-5


  1. Kurachi, K. and Davie, E.W.
    Human factor XI (plasma thromboplastin antecedent).
    Methods Enzymol. 80C : 211-220 (1981).
  2. Cho, K., Tanaka, T., Cook, R.R., Kisiel, W., Fujikawa, K., Kurachi, K. and Powers, J.C.
    Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
    Biochemistry 23 : 644-650 (1984). [PMID: 6370301]
  3. Fujikawa, K., Chung, D.W., Hendrickson, L.E. and Davie, E.W.
    Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein.
    Biochemistry 25 : 2417-2424 (1986). [PMID: 3636155]

[EC created 1978]