EC - Lys-Lys/Arg-Xaa endopeptidase

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IntEnz Enzyme Nomenclature


Accepted name:
Lys-Lys/Arg-Xaa endopeptidase
Other names:
ASP (Aeromonas sobria)-type peptidase
Aeromonas extracellular serine protease
Systematic name:



The enzyme is a serine peptidase, which has been shown to cleave prothrombin and prekallikrein. It hydrolyses the complement component C5 releasing complement component C5a.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Kobayashi, H., Utsunomiya, H., Yamanaka, H., Sei, Y., Katunuma, N., Okamoto, K., Tsuge, H.
    Structural basis for the kexin-like serine protease from Aeromonas sobria as sepsis-causing factor.
    J. Biol. Chem. 284 : 27655-27663 (2009). [PMID: 19654332]
  2. Nitta, H., Kobayashi, H., Irie, A., Baba, H., Okamoto, K., Imamura, T.
    Activation of prothrombin by ASP, a serine protease released from Aeromonas sobria.
    FEBS Lett. 581 : 5935-5939 (2007). [PMID: 18067862]
  3. Kobayashi, H., Takahashi, E., Oguma, K., Fujii, Y., Yamanaka, H., Negishi, T., Arimoto-Kobayashi, S., Tsuji, T., Okamoto, K.
    Cleavage specificity of the serine protease of Aeromonas sobria, a member of the kexin family of subtilases.
    FEMS Microbiol. Lett. 256 : 165-170 (2006). [PMID: 16487335]
  4. Imamura, T., Nitta, H., Wada, Y., Kobayashi, H., Okamoto, K.
    Impaired plasma clottability induction through fibrinogen degradation by ASP, a serine protease released from Aeromonas sobria.
    FEMS Microbiol. Lett. 284 : 35-42 (2008). [PMID: 18462393]
  5. Nitta, H., Imamura, T., Wada, Y., Irie, A., Kobayashi, H., Okamoto, K., Baba, H.
    Production of C5a by ASP, a serine protease released from Aeromonas sobria.
    J. Immunol. 181 : 3602-3608 (2008). [PMID: 18714034]

[EC created 2013]