EC 3.4.21.117 - Stratum corneum chymotryptic enzyme

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IntEnz Enzyme Nomenclature
EC 3.4.21.117

Names

Accepted name:
stratum corneum chymotryptic enzyme
Other names:
kallikrein 7
SCCE
KLK7
PRSS6
hK7
serine protease 6
Systematic name:
-

Reaction

Comments:

This enzyme has wide substrate specificity, being able to degrade heat-denatured bovine casein and the α-chain of native human fibrinogen. It cleaves the B chain of bovine insulin at Leu6┼Cya7, Tyr16┼Leu17, Phe25┼Tyr26 and Tyr26┼Thr27 [1]. It is thought to play a role in the desquamation (skin-shedding) of the outer layer of skin, the stratum corneum, by degrading intercellular cohesive structures [1,2]. Belongs in peptidase family S1A.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Skytt, A., Strömqvist, M. and Egelrud, T.
    Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme.
    Biochem. Biophys. Res. Commun. 211: 586-589 (1995). [PMID: 7794273]
  2. Egelrud, T.
    Purification and preliminary characterization of stratum corneum chymotryptic enzyme: a proteinase that may be involved in desquamation.
    J. Invest. Dermatol. 101: 200-204 (1993). [PMID: 8393902]
  3. Hansson, L., Strömqvist, M., Bäckman, A., Wallbrandt, P., Carlstein, A. and Egelrud, T.
    Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase.
    J. Biol. Chem. 269: 19420-19426 (1994). [PMID: 8034709]
  4. Yousef, G.M., Scorilas, A., Magklara, A., Soosaipillai, A. and Diamandis, E.P.
    The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family — genomic characterization, mapping, tissue expression and hormonal regulation.
    Gene 254: 119-128 (2000). [PMID: 10974542]
  5. Vasilopoulos, Y., Cork, M.J., Murphy, R., Williams, H.C., Robinson, D.A., Duff, G.W., Ward, S.J. and Tazi-Ahnini, R.
    Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis.
    J. Invest. Dermatol. 123: 62-66 (2004). [PMID: 15191543]

[EC 3.4.21.117 created 2006]