EC - Infectious pancreatic necrosis birnavirus Vp4 peptidase

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IntEnz Enzyme Nomenclature


Accepted name:
infectious pancreatic necrosis birnavirus Vp4 peptidase
Other names:
infectious pancreatic necrosis virus protease
IPNV Vp4 protease
IPNV Vp4 peptidase
NS protease
NS-associated protease
Vp4 protease
Systematic name:



Infectious pancreatic necrosis virus (IPNV) is a birnavirus that causes an acute, contagious disease in young salmonid fish [2]. As with most viruses that infect eukaryotic cells, the proteolytic processing of viral precursor proteins is a crucial step in the life cycle of this virus [2]. pVP2 is converted into VP2 by cleavage near the carboxy end of pVP2. This cleavage is most likely due to host-cell proteases rather than VP4 [2,3]. Differs from most serine peptidases in not having the catalytic triad Ser-His-Asp [2]. Belongs in peptidase family S50.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB


  1. Manning, D.S. and Leong, J.C.
    Expression in Escherichia coli of the large genomic segment of infectious pancreatic necrosis virus.
    Virology 179 : 16-25 (1990). [PMID: 2219718]
  2. Petit, S., Lejal, N., Huet, J.-C. and Delmas, B.
    Active residues and viral substrate cleavage sites of the protease of the birnavirus infectious pancreatic necrosis virus.
    J. Virol. 74 : 2057-2066 (2000). [PMID: 10666235]
  3. Dobos, P.
    The molecular biology of infectious pancreatic necrosis virus (IPNV).
    Annu. Rev. Fish Dis. 5 : 25-54 (1995).

[EC created 2006]