EC 22.214.171.124 - Infectious pancreatic necrosis birnavirus Vp4 peptidase
IntEnz Enzyme Nomenclature
IPNV Vp4 protease
IPNV Vp4 peptidase
- Cleaves the (Ser/Thr)-Xaa-Ala(Ser/Ala)-Gly motif in the polyprotein NH2-pVP2-VP4-VP3-COOH of infectious pancreatic necrosis virus at the pVP2-VP4 and VP4-VP3 junctions
Infectious pancreatic necrosis virus (IPNV) is a birnavirus that causes an acute, contagious disease in young salmonid fish . As with most viruses that infect eukaryotic cells, the proteolytic processing of viral precursor proteins is a crucial step in the life cycle of this virus . pVP2 is converted into VP2 by cleavage near the carboxy end of pVP2. This cleavage is most likely due to host-cell proteases rather than VP4 [2,3]. Differs from most serine peptidases in not having the catalytic triad Ser-His-Asp . Belongs in peptidase family S50.
Links to other databases
Expression in Escherichia coli of the large genomic segment of infectious pancreatic necrosis virus.Virology 179 : 16-25 (1990). [PMID: 2219718]
Active residues and viral substrate cleavage sites of the protease of the birnavirus infectious pancreatic necrosis virus.J. Virol. 74 : 2057-2066 (2000). [PMID: 10666235]
The molecular biology of infectious pancreatic necrosis virus (IPNV).Annu. Rev. Fish Dis. 5 : 25-54 (1995).
[EC 126.96.36.199 created 2006]