EC 3.4.21.10 - Acrosin
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 3.4.21.10
Names
Accepted name:
acrosin
Other
names:
α-acrosin
β-acrosin
ψ-acrosin
acrosin amidase
acrosomal protease
acrosomal proteinase
acrozonase
β-acrosin
ψ-acrosin
acrosin amidase
acrosomal protease
acrosomal proteinase
acrozonase
Systematic name:
-
Reaction
- Preferential cleavage: ArgXaa, LysXaa.
Comments:
Occurs in spermatozoa; formed from proacrosin by limited proteolysis. Inhibited by naturally occurring trypsin inhibitors. In peptidase family S1 (trypsin family).
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
MEROPS
,
UniPathway
Protein domains and families:
PROSITE:PDOC00124
Gene Ontology:
GO:0004252
CAS Registry Number:
9068-57-9
UniProtKB/Swiss-Prot:
ACRO_CAPHI
ACRO_HUMAN
ACRO_MELGA
ACRO_MOUSE
ACRO_PIG
ACRO_RABIT
ACRO_RAT
ACRO_SHEEP
References
-
Sperm acrosin.Methods Enzymol. 80C : 621-632 (1981). [PMID: 7043204]
-
The specificity of two proteinases that cleave adjacent to arginine, C1 esterase and acrosin, for peptide p-nitroanilide substrates.Biochim. Biophys. Acta 996 : 89-94 (1989). [PMID: 2500154]
-
Nucleotide sequence and exon-intron organisation of the human proacrosin gene.Eur. J. Biochem. 190 : 195-200 (1990). [PMID: 2114285]
[EC 3.4.21.10 created 1972]