EC 3.4.21.10 - Acrosin

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IntEnz Enzyme Nomenclature
EC 3.4.21.10

Names

Accepted name:
acrosin
Other names:
α-acrosin
β-acrosin
ψ-acrosin
acrosin amidase
acrosomal protease
acrosomal proteinase
acrozonase
Systematic name:
-

Reaction

Comments:

Occurs in spermatozoa; formed from proacrosin by limited proteolysis. Inhibited by naturally occurring trypsin inhibitors. In peptidase family S1 (trypsin family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004252
CAS Registry Number: 9068-57-9
UniProtKB/Swiss-Prot:

References

  1. Müller-Esterl, W. and Fritz, H.
    Sperm acrosin.
    Methods Enzymol. 80C : 621-632 (1981). [PMID: 7043204]
  2. Skoog, M.T., Mehdi, S., Wiseman, J.S. and Bey, P.
    The specificity of two proteinases that cleave adjacent to arginine, C1 esterase and acrosin, for peptide p-nitroanilide substrates.
    Biochim. Biophys. Acta 996 : 89-94 (1989). [PMID: 2500154]
  3. Keime, S., Adham, I.M. and Engel, W.
    Nucleotide sequence and exon-intron organisation of the human proacrosin gene.
    Eur. J. Biochem. 190 : 195-200 (1990). [PMID: 2114285]

[EC 3.4.21.10 created 1972]