EC - Pyroglutamyl-peptidase II

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IntEnz Enzyme Nomenclature


Accepted name:
pyroglutamyl-peptidase II
Other names:
pyroglutamate aminopeptidase II
pyroglutamyl aminopeptidase II
pyroglutamyl peptidase II
thyroliberin-hydrolyzing pyroglutamate aminopeptidase
thyrotropin-releasing factor pyroglutamate aminopeptidase
thyrotropin-releasing hormone-degrading peptidase
thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase
Systematic name:




Highly specific for thyrotropin releasing hormone (pyroglutamyl-histidyl-prolylamide). Will not cleave the pyroglutamyl-histidyl bond of luteinizing hormone releasing hormone. Found in serum and brain. Inhibited by metal chelators. In peptidase family M1 (membrane alanyl aminopeptidase family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016921
CAS Registry Number: 60063-88-9


  1. Bauer, K. and Nowak, P.
    Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond.
    Eur. J. Biochem. 99: 239-246 (1979). [PMID: 115687]
  2. O'Connor, B. and O'Cuinn, G.
    Purification of and kinetic studies on a narrow specifity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain.
    Eur. J. Biochem. 150: 47-52 (1985). [PMID: 2862039]
  3. Wilk, S. and Wilk, E.K.
    Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme.
    Neurochem. Int. 15: 81-89 (1989).

[EC created 1992]