EC - Pyroglutamyl-peptidase I

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IntEnz Enzyme Nomenclature


Accepted name:
pyroglutamyl-peptidase I
Other names:
L-pyroglutamyl peptide hydrolase
L-pyrrolidonecarboxylate peptidase
pyroglutamate aminopeptidase
pyroglutamyl aminopeptidase
pyrrolidone-carboxyl peptidase
pyrrolidonecarboxylyl peptidase
pyrrolidonyl peptidase
Systematic name:



A cysteine peptidase, known from bacteria, plants and animals. The enzyme from bacterial sources is used in protein sequencing, and is the type example of peptidase family C15. Formerly EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC01036
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004219
CAS Registry Number: 9075-21-2
UniProtKB/Swiss-Prot: (149) [show] [UniProt]


  1. Tsuru, D., Nakamura, K., Yoshimoto, T. and Fujiwara, K.
    Pyroglutamyl-peptidase from Bacillus amyloliquefaciens. An improved purification method and some properties of the enzyme.
    Biochim. Biophys. Acta 791: 117-122 (1984).
  2. Awadé, A.C., Cleuziat, P., Gonzalès, T. and Robert-Baudouy, J.
    Pyrrolidone carboxyl peptidase (Pcp): an enzyme that removes pyroglutamic acid (pGlu) from pGlu-peptides and pGlu-proteins.
    Proteins: Struct. Funct. Genet. 20: 34-51 (1994). [PMID: 7824521]
  3. Patti, J.M., Schneider, A., Garza, N. and Boles, J.O.
    Isolation and characterization of pcp, a gene encoding a pyrrolidone carboxyl peptidase in Staphylococcus aureus.
    Gene 166: 95-99 (1995). [PMID: 8529900]
  4. Le Saux, O., Gonzalès, T. and Robert-Baudouy, J.
    Mutational analysis of the active site of Pseudomonas fluorescens pyrrolidone carboxyl peptidase.
    J. Bacteriol. 178: 3308-3313 (1996). [PMID: 8655512]

[EC created 1972 as EC, transferred 1981 to EC, modified 1997]