EC 3.4.19.12
- Ubiquitinyl hydrolase 1
IntEnz Enzyme Nomenclature
EC 3.4.19.12
Names
Accepted name:
ubiquitinyl hydrolase 1
Other
names:
ubiquitin C-terminal hydrolase
yeast ubiquitin hydrolase
ubiquitin thiolesterase
ubiquitin carboxyl-terminal hydrolase
Reaction
-
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Comments:
Links to polypeptides smaller than 60 residues are hydrolysed more readily than those to larger polypeptides. Isoforms exist with quantitatively different specificities, amongst the best known being UCH-L1 and UCH-L3, which are major proteins of the brain of mammals [1]. Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). Ubiquitinyl hydrolase 1 is the type example of peptidase family C12, with a similar protein fold to papain and catalytic amino acids Cys, His and Asp. There is a separate family (C19) of enzymes that also hydrolyse ubiquitinyl bonds, and it is thought that all the ubiquitinyl hydrolases are also ubiquitin thioesterases (EC 3.1.2.15).
Links to other databases
CAS Registry Numbers:
189642-63-5
86480-67-3
ALG13-2_HUMAN
ALG13-2_MOUSE
ALG13-3_HUMAN
ALG13-4_HUMAN
ALG13_HUMAN
ALG13_MOUSE
ATX3-1_HUMAN
ATX3-3_HUMAN
ATX3-4_HUMAN
ATX3-5_HUMAN
ATX3H_ARATH
ATX3L_HUMAN
ATX3_CAEBR
ATX3_CAEEL
ATX3_CHICK
ATX3_HUMAN
ATX3_MOUSE
ATX3_ORYSJ
ATX3_RAT
BAP1_BOVIN
BAP1_BRAFL
BAP1_CHICK
BAP1_DANRE
BAP1_HUMAN
BAP1_MOUSE
BAP1_RAT
BAP1_XENLA
BAP1_XENTR
CALYP_AEDAE
CALYP_CULQU
CALYP_DROAN
CALYP_DROER
CALYP_DROGR
CALYP_DROME
CALYP_DROMO
CALYP_DROPE
CALYP_DROPS
CALYP_DROSE
CALYP_DROSI
CALYP_DROVI
CALYP_DROYA
CREB_ASPCL
CREB_ASPFC
CREB_ASPFN
CREB_ASPFU
CREB_ASPNC
CREB_ASPOR
CREB_ASPTN
CREB_EMENI
CREB_NEOFI
CYLD-2_HUMAN
CYLD-2_MOUSE
CYLD-3_MOUSE
CYLD_BOVIN
CYLD_HUMAN
CYLD_MOUSE
CYLD_PONAB
CYLD_RAT
DESI2-2_HUMAN
DESI2_CHICK
DESI2_DANRE
DESI2_HUMAN
DESI2_MOUSE
DESI2_PIG
DESI2_PONAB
DESI2_RAT
DESI2_XENLA
EIF3F_HUMAN
EIF3F_MACFA
EIF3F_MOUSE
EIF3F_PANTR
FAF-3_DROME
FAF_DROME
JOS1_BOVIN
JOS1_HUMAN
JOS1_MOUSE
JOS1_PONAB
JOS1_RAT
JOS2-2_HUMAN
JOS2_HUMAN
JOS2_MOUSE
JOSL_ARATH
JOSL_DROME
LTP_ALHV1
LTP_EBVA8
LTP_EBVB9
LTP_EBVG
LTP_EHV1B
LTP_EHV2
LTP_GAHVM
LTP_HCMVA
LTP_HCMVM
LTP_HCMVT
LTP_HHV11
LTP_HHV2H
LTP_HHV6G
LTP_HHV6U
LTP_HHV6Z
LTP_HHV7J
LTP_HHV8P
LTP_MHV68
LTP_MUHVK
LTP_PSHV1
LTP_SHV21
LTP_VZVD
LTP_VZVO
L_CCHFI
L_DUGBA
MINY1-2_HUMAN
MINY1-2_MOUSE
MINY1-3_HUMAN
MINY1-3_MOUSE
MINY1-4_HUMAN
MINY1_BOVIN
MINY1_DANRE
MINY1_HUMAN
MINY1_MOUSE
MINY1_PONAB
MINY1_RAT
MINY2-2_HUMAN
MINY2-2_MOUSE
MINY2-3_MOUSE
MINY2_BOVIN
MINY2_HUMAN
MINY2_MOUSE
MINY3-2_HUMAN
MINY3-2_MACFA
MINY3-2_MOUSE
MINY3_BOVIN
MINY3_DANRE
MINY3_DROME
MINY3_HUMAN
MINY3_MACFA
MINY3_MOUSE
MINY3_XENTR
MINY4-2_MOUSE
MINY4_BOVIN
MINY4_HUMAN
MINY4_MOUSE
MINY4_PONAB
MINY4_XENTR
MU105_SCHPO
NOT_DROME
OTU1-2_HUMAN
OTU10-2_ARATH
OTU10_ARATH
OTU11-2_ARATH
OTU11_ARATH
OTU12-2_ARATH
OTU12_ARATH
OTU1_ARATH
OTU1_BOVIN
OTU1_CHICK
OTU1_DANRE
OTU1_DICDI
OTU1_DROME
OTU1_DROPS
OTU1_HUMAN
OTU1_MOUSE
OTU1_RAT
OTU1_SCHPO
OTU1_XENLA
OTU1_YEAST
OTU2_ARATH
OTU2_SCHPO
OTU3_ARATH
OTU4-2_ARATH
OTU4-3_ARATH
OTU4-4_ARATH
OTU4-5_ARATH
OTU4_ARATH
OTU5-2_ARATH
OTU5A-2_DANRE
OTU5A_DANRE
OTU5A_XENLA
OTU5B_XENLA
OTU5_ARATH
OTU6-2_ARATH
OTU6A_HUMAN
OTU6A_MOUSE
OTU6B-2_HUMAN
OTU6B_CHICK
OTU6B_DANRE
OTU6B_HUMAN
OTU6B_MOUSE
OTU6B_XENLA
OTU6B_XENTR
OTU6_ARATH
OTU7-2_ARATH
OTU7A-2_HUMAN
OTU7A_HUMAN
OTU7A_MOUSE
OTU7B-2_HUMAN
OTU7B_HUMAN
OTU7B_MOUSE
OTU7_ARATH
OTU8_ARATH
OTU9_ARATH
OTUB1-2_HUMAN
OTUB1_HUMAN
OTUB1_MOUSE
OTUB1_RAT
OTUB2-2_HUMAN
OTUB2_HUMAN
OTUB2_MOUSE
OTUBL_CAEBR
OTUBL_CAEEL
OTUBL_DROME
OTUD1_HUMAN
OTUD1_MOUSE
OTUD3_HUMAN
OTUD3_MOUSE
OTUD4-3_HUMAN
OTUD4-4_HUMAN
OTUD4-5_HUMAN
OTUD4_HUMAN
OTUD4_MOUSE
OTUD5-2_HUMAN
OTUD5-2_MOUSE
OTUD5-2_RAT
OTUD5-3_HUMAN
OTUD5-4_HUMAN
OTUD5-5_HUMAN
OTUD5_HUMAN
OTUD5_MOUSE
OTUD5_RAT
OTUD5_XENTR
OTUL_HUMAN
OTUL_MOUSE
POLG_SVV1
PUF-2_DROME
PUF_DROME
R1AB-2_FIPV
R1AB_BC133
R1AB_BC279
R1AB_BC512
R1AB_BCHK3
R1AB_BCHK4
R1AB_BCHK5
R1AB_BCHK9
R1AB_BCRP3
R1AB_CVBEN
R1AB_CVBLU
R1AB_CVBM
R1AB_CVBQ
R1AB_CVH22
R1AB_CVHN1
R1AB_CVHN2
R1AB_CVHN5
R1AB_CVHNL
R1AB_CVHOC
R1AB_CVM2
R1AB_CVMA5
R1AB_CVMJH
R1AB_CVPPU
R1AB_FIPV
R1AB_IBVB
R1AB_IBVBC
R1AB_IBVM
R1AB_MERS1
R1AB_PEDV7
R1AB_SARS
R1AB_SARS2
R1A_BC133
R1A_BC279
R1A_BC512
R1A_BCHK3
R1A_BCHK4
R1A_BCHK5
R1A_BCHK9
R1A_BCRP3
R1A_CVBEN
R1A_CVBLU
R1A_CVBM
R1A_CVBQ
R1A_CVH22
R1A_CVHN1
R1A_CVHN2
R1A_CVHN5
R1A_CVHNL
R1A_CVHOC
R1A_CVM2
R1A_CVMA5
R1A_CVMJH
R1A_CVPPU
R1A_IBVB
R1A_IBVBC
R1A_IBVM
R1A_MERS1
R1A_PEDV7
R1A_SARS
R1A_SARS2
RPN11_YEAST
RPOA-2_EAVBU
RPOA-2_PRRS1
RPOA-2_PRRSB
RPOA-2_PRRSL
RPOA-2_PRRSR
RPOA-2_PRRSS
RPOA_EAVBU
RPOA_PRRS1
RPOA_PRRSB
RPOA_PRRSL
RPOA_PRRSR
RPOA_PRRSS
TNAP3_HUMAN
TNAP3_MACFA
TNAP3_MOUSE
TRBID_DROME
U17L1_HUMAN
U17L2_HUMAN
U17L3_HUMAN
U17L5_HUMAN
U17L6_HUMAN
U17LA_HUMAN
U17LB_HUMAN
U17LC_MOUSE
U17LD_HUMAN
U17LF_HUMAN
U17LH_HUMAN
U17LI_HUMAN
U17LJ_HUMAN
U17LK_HUMAN
U17LL_HUMAN
U17LM_HUMAN
U17LO_HUMAN
U17PA_MOUSE
U17PB-2_MOUSE
U17PB_MOUSE
U17PD_MOUSE
U17PE_MOUSE
UB10A_XENLA
UB10B_XENLA
UB12A_XENLA
UB12B_XENLA
UB22A_XENLA
UB22B_XENLA
UBH4_CAEEL
UBL1_YEAST
UBLH1_SCHPO
UBLH2_SCHPO
UBP10-2_HUMAN
UBP10-2_MOUSE
UBP10-3_HUMAN
UBP10_ARATH
UBP10_BOVIN
UBP10_CHICK
UBP10_HUMAN
UBP10_MOUSE
UBP10_RAT
UBP10_XENTR
UBP10_YEAST
UBP11_ARATH
UBP11_CANLF
UBP11_HUMAN
UBP11_MOUSE
UBP11_RAT
UBP11_SCHPO
UBP11_YEAST
UBP12-2_ARATH
UBP12-2_MOUSE
UBP12_ARATH
UBP12_BOVIN
UBP12_DANRE
UBP12_HUMAN
UBP12_MOUSE
UBP12_SALSA
UBP12_SCHPO
UBP12_YEAST
UBP13-2_HUMAN
UBP13_ARATH
UBP13_BOVIN
UBP13_CHICK
UBP13_DANRE
UBP13_HUMAN
UBP13_MOUSE
UBP13_XENTR
UBP13_YEAST
UBP14-2_HUMAN
UBP14-3_HUMAN
UBP14_ARATH
UBP14_BOVIN
UBP14_CAEEL
UBP14_HUMAN
UBP14_MOUSE
UBP14_PANTR
UBP14_RABIT
UBP14_SCHPO
UBP14_YEAST
UBP15-2_HUMAN
UBP15-2_MOUSE
UBP15-2_XENTR
UBP15-3_HUMAN
UBP15-3_MOUSE
UBP15-4_HUMAN
UBP15-4_MOUSE
UBP15-5_MOUSE
UBP15_ARATH
UBP15_BOVIN
UBP15_HUMAN
UBP15_MOUSE
UBP15_ORYSJ
UBP15_RAT
UBP15_XENTR
UBP15_YEAST
UBP16-2_HUMAN
UBP16-2_MACFA
UBP16-2_RAT
UBP16-3_HUMAN
UBP16-4_HUMAN
UBP16-5_HUMAN
UBP16_ARATH
UBP16_BOVIN
UBP16_DANRE
UBP16_EMENI
UBP16_HUMAN
UBP16_MACFA
UBP16_MOUSE
UBP16_RAT
UBP16_SCHPO
UBP16_XENLA
UBP16_XENTR
UBP16_YEAST
UBP17-2_ARATH
UBP17_ARATH
UBP18_ARATH
UBP19-2_HUMAN
UBP19-2_MOUSE
UBP19-3_HUMAN
UBP19-4_HUMAN
UBP19-5_HUMAN
UBP19-6_HUMAN
UBP19-7_HUMAN
UBP19_ARATH
UBP19_HUMAN
UBP19_MOUSE
UBP19_RAT
UBP1_ARATH
UBP1_BOVIN
UBP1_HUMAN
UBP1_MOUSE
UBP1_RAT
UBP1_SCHPO
UBP1_YEAST
UBP2-2_DROME
UBP2-2_HUMAN
UBP2-2_MOUSE
UBP2-2_RAT
UBP2-3_HUMAN
UBP2-3_MOUSE
UBP2-4_HUMAN
UBP2-4_MOUSE
UBP20_ARATH
UBP20_BOVIN
UBP20_DANRE
UBP20_HUMAN
UBP20_MOUSE
UBP20_PONAB
UBP20_XENLA
UBP20_XENTR
UBP21-2_HUMAN
UBP21-3_HUMAN
UBP21_ARATH
UBP21_BOVIN
UBP21_HUMAN
UBP21_MOUSE
UBP21_RAT
UBP21_SCHPO
UBP22-2_DANRE
UBP22-2_HUMAN
UBP22_ARATH
UBP22_BOVIN
UBP22_DANRE
UBP22_HUMAN
UBP22_MOUSE
UBP23_ARATH
UBP24-2_MOUSE
UBP24_ARATH
UBP24_HUMAN
UBP24_MOUSE
UBP25-1_HUMAN
UBP25-3_HUMAN
UBP25_ARATH
UBP25_HUMAN
UBP25_MOUSE
UBP26_ARATH
UBP26_HUMAN
UBP26_MOUSE
UBP26_ORYSI
UBP26_ORYSJ
UBP27-2_ARATH
UBP27_ARATH
UBP27_HUMAN
UBP27_MOUSE
UBP28-2_HUMAN
UBP28-2_MOUSE
UBP28-2_RAT
UBP28-3_HUMAN
UBP28_CHICK
UBP28_HUMAN
UBP28_MOUSE
UBP28_RAT
UBP29_HUMAN
UBP29_MOUSE
UBP2_ARATH
UBP2_BOVIN
UBP2_CHICK
UBP2_DROME
UBP2_HUMAN
UBP2_KLULA
UBP2_MOUSE
UBP2_RAT
UBP2_SCHPO
UBP2_YEAST
UBP3-2_HUMAN
UBP30_DANRE
UBP30_DROME
UBP30_HUMAN
UBP30_MOUSE
UBP30_RAT
UBP30_XENTR
UBP31-2_HUMAN
UBP31_HUMAN
UBP32-2_DROME
UBP32-2_HUMAN
UBP32-3_DROME
UBP32-4_DROME
UBP32_DROME
UBP32_HUMAN
UBP33-2_HUMAN
UBP33-2_MOUSE
UBP33-3_HUMAN
UBP33_BOVIN
UBP33_DANRE
UBP33_HUMAN
UBP33_MOUSE
UBP33_PONAB
UBP33_XENTR
UBP34-2_HUMAN
UBP34-2_MOUSE
UBP34-3_HUMAN
UBP34-3_MOUSE
UBP34-4_MOUSE
UBP34_HUMAN
UBP34_MOUSE
UBP35-2_HUMAN
UBP35_HUMAN
UBP36-2_DROME
UBP36-6_DROME
UBP36-7_DROME
UBP36-8_DROME
UBP36-9_DROME
UBP36_DROAN
UBP36_DROER
UBP36_DROGR
UBP36_DROME
UBP36_DROMO
UBP36_DROPS
UBP36_DROSE
UBP36_DROSI
UBP36_DROVI
UBP36_DROWI
UBP36_DROYA
UBP36_HUMAN
UBP36_MOUSE
UBP37-2_HUMAN
UBP37-2_MOUSE
UBP37_BOVIN
UBP37_CANLF
UBP37_CHICK
UBP37_DANRE
UBP37_HUMAN
UBP37_MOUSE
UBP37_PIG
UBP38-2_HUMAN
UBP38_HUMAN
UBP38_MOUSE
UBP3_ARATH
UBP3_HUMAN
UBP3_MOUSE
UBP3_SCHPO
UBP3_YEAST
UBP4-2_HUMAN
UBP4-3_HUMAN
UBP40-2_HUMAN
UBP40-2_MOUSE
UBP40-3_HUMAN
UBP40-3_MOUSE
UBP40-4_MOUSE
UBP40_HUMAN
UBP40_MOUSE
UBP41_HUMAN
UBP42-2_HUMAN
UBP42_BOVIN
UBP42_HUMAN
UBP42_MOUSE
UBP42_RAT
UBP43-2_HUMAN
UBP43-2_MOUSE
UBP43-3_HUMAN
UBP43-4_HUMAN
UBP43_HUMAN
UBP43_MOUSE
UBP44_AILME
UBP44_DANRE
UBP44_HUMAN
UBP44_MOUSE
UBP44_XENTR
UBP45-2_HUMAN
UBP45-2_MOUSE
UBP45-3_HUMAN
UBP45_DANRE
UBP45_HUMAN
UBP45_MOUSE
UBP46-2_CAEEL
UBP46-2_HUMAN
UBP46-2_PONAB
UBP46-3_HUMAN
UBP46-4_HUMAN
UBP46_CAEEL
UBP46_DANRE
UBP46_HUMAN
UBP46_MOUSE
UBP46_PONAB
UBP46_RAT
UBP47-2_HUMAN
UBP47-2_MOUSE
UBP47-3_HUMAN
UBP47-4_HUMAN
UBP47_CHICK
UBP47_HUMAN
UBP47_MOUSE
UBP47_XENLA
UBP47_XENTR
UBP48-2_CAEEL
UBP48-2_HUMAN
UBP48-2_MOUSE
UBP48-3_HUMAN
UBP48-3_MOUSE
UBP48-4_HUMAN
UBP48-4_MOUSE
UBP48-5_HUMAN
UBP48-5_MOUSE
UBP48-6_HUMAN
UBP48-7_HUMAN
UBP48-8_HUMAN
UBP48_CAEEL
UBP48_CHICK
UBP48_HUMAN
UBP48_MOUSE
UBP48_RAT
UBP49-2_HUMAN
UBP49_HUMAN
UBP49_MOUSE
UBP4_ARATH
UBP4_ASHGO
UBP4_BOVIN
UBP4_CANGA
UBP4_HUMAN
UBP4_KLULA
UBP4_MOUSE
UBP4_PONAB
UBP4_RAT
UBP4_SCHPO
UBP4_VANPO
UBP4_YEAS1
UBP4_YEAS7
UBP4_YEAST
UBP5-2_HUMAN
UBP50-2_MOUSE
UBP50_MACFA
UBP50_MOUSE
UBP51_HUMAN
UBP51_MOUSE
UBP5_ARATH
UBP5_HUMAN
UBP5_MOUSE
UBP5_PONAB
UBP5_SCHPO
UBP5_YEAST
UBP6-2_HUMAN
UBP6-3_HUMAN
UBP6_ARATH
UBP6_HUMAN
UBP6_SCHPO
UBP6_YEAST
UBP7-2_CHICK
UBP7-2_MOUSE
UBP7-3_CHICK
UBP7-3_HUMAN
UBP7-3_MOUSE
UBP7_ARATH
UBP7_CAEBR
UBP7_CAEEL
UBP7_CHICK
UBP7_DROME
UBP7_HUMAN
UBP7_MOUSE
UBP7_RAT
UBP7_SCHPO
UBP7_YEAST
UBP8-2_HUMAN
UBP8_ARATH
UBP8_HUMAN
UBP8_MOUSE
UBP8_SCHPO
UBP8_YEAST
UBP9_ARATH
UBP9_SCHPO
UBP9_YEAST
UBPA_DICDI
UBPB_DICDI
UBPE-2_DROME
UBPE_DROME
UBPH-2_CAEEL
UBPH_CAEEL
UBPL1_MIMIV
UBPL2_MIMIV
UBPY_CAEEL
UCH1_ARATH
UCH2_ARATH
UCH37_PLAF7
UCH3_ARATH
UCHL1_BOVIN
UCHL1_HORSE
UCHL1_HUMAN
UCHL1_MACFA
UCHL1_MONDO
UCHL1_MOUSE
UCHL1_PIG
UCHL1_RAT
UCHL3_BOVIN
UCHL3_HUMAN
UCHL3_MOUSE
UCHL3_PIG
UCHL3_PLAF7
UCHL3_RAT
UCHL4_MOUSE
UCHL5-2_HUMAN
UCHL5-2_MOUSE
UCHL5-3_HUMAN
UCHL5-4_HUMAN
UCHL5_BOVIN
UCHL5_DICDI
UCHL5_HUMAN
UCHL5_MOUSE
UCHL5_PIG
UCHL_APLCA
UCHL_DICDI
UCHL_DROME
UL17C_HUMAN
UP44A_XENLA
UP44B_XENLA
USP9X-3_HUMAN
USP9X_HUMAN
USP9X_MOUSE
USP9Y-2_HUMAN
USP9Y_HUMAN
VCIP1-2_MOUSE
VCIP1_HUMAN
VCIP1_MOUSE
VCIP1_RAT
VF232_IIV3
VF232_IIV6
VL96_IRV1
YP191_YEAST
ZRAN1_BOVIN
ZRAN1_HUMAN
ZRAN1_MOUSE
ZRAN1_XENTR
ZRN1A_XENLA
ZRN1B_DANRE
ZRN1B_XENLA
ZUP1-2_HUMAN
ZUP1-2_MOUSE
ZUP1-3_MOUSE
ZUP1-4_MOUSE
ZUP1_BOVIN
ZUP1_HUMAN
ZUP1_MACFA
ZUP1_MOUSE
ZUP1_RAT
References
-
Johnston, S.C., Larsen, C.N., Cook, W.J., Wilkinson, K.D. and Hill, C.P.
Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8Å resolution.
EMBO J.
16
:
3787-3796
(1997).
[PMID:
9233788]
-
Wilkinson, K.D.
Ubiquitin C-terminal hydrolase.
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.)
Handbook of Proteolytic Enzymes
, Academic Press
, London
, 1998
,
470-472
[EC 3.4.19.12 created 2000]