EC - γ-D-glutamyl-meso-diaminopimelate peptidase

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IntEnz Enzyme Nomenclature


Accepted name:
γ-D-glutamyl-meso-diaminopimelate peptidase
Other names:
γ-D-glutamyl-meso-D-aminopimelic endopeptidase
γ-D-glutamyl-meso-diaminopimelate endopeptidase
γ-D-glutamyl-meso-diaminopimelic endopeptidase
γ-D-glutamyl-meso-diaminopimelic peptidoglycan hydrolase
γ-D-glutamyl-L-meso-diaminopimelate peptidoglycan hydrolase
γ-D-glutamyldiaminopimelate endopeptidase
γ-glutamyl-L-meso-diaminopimelyl endopeptidase
endopeptidase I
Systematic name:



A 45-kDa metallopeptidase from Bacillus sphaericus, the substrates being components of the bacterial spore wall. A member of peptidase family M14 (carboxypeptidase A family). Endopeptidase II has similar activity, but differs in cellular location, molecular mass and catalytic mechanism [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB
CAS Registry Number: 62572-28-5


  1. Arminjon, F., Guinand, M., Vacheron, M.-J. and Michel, G.
    Specificity profiles of the membrane-bound γ-D-glutamyl-(L)meso-diaminopimelate endopeptidase and LD-carboxypeptidase from Bacillus sphaericus 9602.
    Eur. J. Biochem. 73 : 557-565 (1977). [PMID: 849747]
  2. Garnier, M., Vacheron, M.-J., Guinard, M. and Michel, G.
    Purification and partial characterization of the extracellular γ-D-glutamyl-(L)meso-diaminopimelate endopeptidase I, from Bacillus sphaericus NCTC 9602.
    Eur. J. Biochem. 148 : 539-543 (1985). [PMID: 3922755]
  3. Hourdou, M.-L., Guinand, M., Vacheron, M.-J., Michel, G., Denoroy, L., Duez, C., Englebert, S., Joris, B., Weber, G. and Ghuysen, J.-M.
    Characterization of the sporulation-related γ-D-glutamyl-(L)meso-diaminopimelic-acid-hydrolysing peptidase I of Bacillus sphaericus NCTC 9602 as a member of the metallo(zinc) carboxypeptidase A family. Modular design of the protein.
    Biochem. J. 292 : 563-570 (1993). [PMID: 8503890]

[EC created 1996]