EC 3.4.17.24 - Tubulin-glutamate carboxypeptidase

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IntEnz Enzyme Nomenclature
EC 3.4.17.24

Names

Accepted name:
tubulin-glutamate carboxypeptidase
Other names:
cytosolic carboxypeptidase 1
cytosolic carboxypeptidase 5
Systematic name:
-

Reactions

Comments:

This is a subfamily of enzymes that cleave C-terminal and/or side chain amino acids from tubulins. The dual-specificity enzymes can cleave both α- and γ-linked L-glutamate from tubulins, removing the posttranslationally added polyglutamyl side chains from the C-terminal regions. In addition, the enzyme removes two glutamate residues from the C-terminus of β-tubulin and detyrosinated α-tubulin (from which the C-terminal L-tyrosine has been removed by EC 3.4.17.17). The latter is cleaved to Δ2-tubulin and further to Δ3-tubulin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (36) [show] [UniProt]

References

  1. Rogowski, K., van Dijk, J., Magiera, M. M., Bosc, C., Deloulme, J. C., Bosson, A., Peris, L., Gold, N. D., Lacroix, B., Bosch Grau, M., Bec, N., Larroque, C., Desagher, S., Holzer, M., Andrieux, A., Moutin, M. J., Janke, C.
    A family of protein-deglutamylating enzymes associated with neurodegeneration.
    Cell 143 : 564-578 (2010). [PMID: 21074048]
  2. Kimura, Y., Kurabe, N., Ikegami, K., Tsutsumi, K., Konishi, Y., Kaplan, O. I., Kunitomo, H., Iino, Y., Blacque, O. E., Setou, M.
    Identification of tubulin deglutamylase among Caenorhabditis elegans and mammalian cytosolic carboxypeptidases (CCPs).
    J. Biol. Chem. 285 : 22936-22941 (2010). [PMID: 20519502]
  3. Berezniuk, I., Vu, H. T., Lyons, P. J., Sironi, J. J., Xiao, H., Burd, B., Setou, M., Angeletti, R. H., Ikegami, K., Fricker, L. D.
    Cytosolic carboxypeptidase 1 is involved in processing alpha- and gamma-tubulin.
    J. Biol. Chem. 287 : 6503-6517 (2012). [PMID: 22170066]
  4. Berezniuk, I., Lyons, P. J., Sironi, J. J., Xiao, H., Setou, M., Angeletti, R. H., Ikegami, K., Fricker, L. D.
    Cytosolic carboxypeptidase 5 removes alpha- and gamma-linked glutamates from tubulin.
    J. Biol. Chem. 288 : 30445-30453 (2013). [PMID: 24022482]
  5. Pathak, N., Austin-Tse, C. A., Liu, Y., Vasilyev, A., Drummond, I. A.
    Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function.
    Mol. Biol. Cell 25 : 1836-1844 (2014). [PMID: 24743595]

[EC 3.4.17.24 created 2020]