EC 3.4.16.2 - Lysosomal Pro-Xaa carboxypeptidase

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IntEnz Enzyme Nomenclature
EC 3.4.16.2

Names

Accepted name:
lysosomal Pro-Xaa carboxypeptidase
Other names:
PCP
aminoacylproline carboxypeptidase
angiotensinase C
carboxypeptidase P
lysosomal Pro-X carboxypeptidase
lysosomal carboxypeptidase C
peptidylprolylamino acid carboxypeptidase
proline-specific carboxypeptidase P
prolyl carboxypeptidase
Systematic name:

Reaction

Comments:

A lysosomal peptidase active at acidic pH that inactivates angiotensin II. Inhibited by diisopropyl fluorophosphate. In peptidase family S28 (Pro-Xaa carboxypeptidase family). Formerly EC 3.4.12.4.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004185
CAS Registry Number: 9075-64-3
UniProtKB/Swiss-Prot:

References

  1. Walter, R., Simmons, W.H. and Yoshimoto, T.
    Proline specific endo- and exopeptidases.
    Mol. Cell. Biochem. 30 : 111-127 (1980). [PMID: 6991912]
  2. Odya, C.E. and Erdös, E.G.
    Human prolylcarboxypeptidase.
    Methods Enzymol. 80 : 460-466 (1981). [PMID: 7341916]

[EC 3.4.16.2 created 1972 as EC 3.4.12.4, transferred 1978 to EC 3.4.16.2]