EC - Peptidyl-dipeptidase B

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IntEnz Enzyme Nomenclature


Accepted name:
peptidyl-dipeptidase B
Other names:
atrial di-(tri)peptidyl carboxyhydrolase
atrial dipeptidyl carboxyhydrolase
atrial peptide convertase
atriopeptin convertase
dipeptidyl carboxyhydrolase
peptidyldipeptidase B
Systematic name:




A membrane-bound, zinc metallopeptidase located in mammalian atrial, but not ventricular, myocytes. Although it is capable of converting the 126-residue atriopeptin III directly to atriopeptin I by releasing a C-terminal tripeptide Phe-Arg-Tyr, it is generally restricted to the release of dipeptides. In contrast to peptidyl-dipeptidase A (EC it displays no Cl- dependence and shows no action on angiotensin I. Conversely, peptidyl-dipeptidase A is unable to release Phe-Arg from the C-terminus of atriopeptin II.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB
CAS Registry Number: 147014-93-5


  1. Harris, R.B. and Wilson, I.B.
    Atrial tissue contains a metallo dipeptidyl carboxyhydrolase not present in ventricular tissue: partial purification and characterization.
    Arch. Biochem. Biophys. 233: 667-675 (1984). [PMID: 6385859]
  2. Harris, R.B. and Wilson, I.B.
    Conversion of atriopeptin II to atriopeptin I by atrial dipeptidyl carboxy hydrolase.
    Peptides (Fayetteville) 6: 393-396 (1985). [PMID: 2999723]
  3. Soler, D.F. and Harris, R.B.
    Continuous fluorogenic substrates for atrial dipeptidyl carboxyhydrolase. Importance of Ser in the P1 position.
    Int. J. Peptide Protein Res. 32: 35-40 (1988). [PMID: 3146555]
  4. Soler, D.F. and Harris, R.B.
    Atrial dipeptidyl carboxyhydrolase is a zinc-metallo proteinase which possesses tripeptidyl carboxyhydrolase activity.
    Peptides (Fayetteville) 10: 63-68 (1989). [PMID: 2501770]

[EC created 1992]