EC 184.108.40.206 - Peptidyl-dipeptidase B
IntEnz Enzyme Nomenclature
atrial dipeptidyl carboxyhydrolase
atrial peptide convertase
- Release of a C-terminal dipeptide or exceptionally a tripeptide.
A membrane-bound, zinc metallopeptidase located in mammalian atrial, but not ventricular, myocytes. Although it is capable of converting the 126-residue atriopeptin III directly to atriopeptin I by releasing a C-terminal tripeptide Phe-Arg-Tyr, it is generally restricted to the release of dipeptides. In contrast to peptidyl-dipeptidase A (EC 220.127.116.11) it displays no Cl- dependence and shows no action on angiotensin I. Conversely, peptidyl-dipeptidase A is unable to release Phe-Arg from the C-terminus of atriopeptin II.
Links to other databases
Atrial tissue contains a metallo dipeptidyl carboxyhydrolase not present in ventricular tissue: partial purification and characterization.Arch. Biochem. Biophys. 233: 667-675 (1984). [PMID: 6385859]
Conversion of atriopeptin II to atriopeptin I by atrial dipeptidyl carboxy hydrolase.Peptides (Fayetteville) 6: 393-396 (1985). [PMID: 2999723]
Continuous fluorogenic substrates for atrial dipeptidyl carboxyhydrolase. Importance of Ser in the P1 position.Int. J. Peptide Protein Res. 32: 35-40 (1988). [PMID: 3146555]
Atrial dipeptidyl carboxyhydrolase is a zinc-metallo proteinase which possesses tripeptidyl carboxyhydrolase activity.Peptides (Fayetteville) 10: 63-68 (1989). [PMID: 2501770]
[EC 18.104.22.168 created 1992]