EC 3.4.15.1 - Peptidyl-dipeptidase A
IntEnz Enzyme Nomenclature
EC 3.4.15.1
Names
DCP
PDH
angiotensin I-converting enzyme
angiotensin converting enzyme
carboxycathepsin
dipeptidase
dipeptide hydrolase [ambiguous]
dipeptidyl carboxypeptidase
dipeptidyl carboxypeptidase I
endothelial cell peptidyl dipeptidase
kininase II
peptidase P
peptidyl dipeptidase A
peptidyl dipeptidase I
peptidyl dipeptidase-4
peptidyl dipeptide hydrolase
peptidyl-dipeptide hydrolase
peptidyldipeptide hydrolase
Reaction
- Release of a C-terminal dipeptide, oligopeptide┼Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.
Cofactor
Comments:
A Cl−-dependent, zinc glycoprotein that is generally membrane-bound. A potent inhibitor is captopril. Important in elevation of blood pressure, through formation of angiotensin II (vasoconstrictor) and destruction of bradykinin (vasodilator). Two molecular forms exist in mammalian tissues, a widely-distributed somatic form of 150- to 180-kDa that contains two non-identical catalytic sites, and a testicular form of 90- to 100-kDa that contains only a single catalytic site. Type example of peptidase family M2.
Links to other databases
References
-
Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning.Proc. Natl. Acad. Sci. USA 85: 9386-9390 (1988). [PMID: 89071703]
-
Molecular cloning of human testicular angiotensin-converting enzyme: the testis enzyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme.Proc. Natl. Acad. Sci. USA 86: 7741-7745 (1989). [PMID: 2554286]
-
The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors.J. Biol. Chem. 267: 13398-13405 (1992). [PMID: 1320019]
-
Peptidyl dipeptidase A: angiotensin I-converting enzyme.Methods Enzymol. 248: 283-305 (1995). [PMID: 7674927]
[EC 3.4.15.1 created 1972, modified 1981, modified 1989, modified 1996, modified 2011]