EC 3.4.15.1 - Peptidyl-dipeptidase A
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 3.4.15.1
Names
Accepted name:
peptidyl-dipeptidase A
Other
names:
ACE
DCP
PDH
angiotensin I-converting enzyme
angiotensin converting enzyme
carboxycathepsin
dipeptidase
dipeptide hydrolase [ambiguous]
dipeptidyl carboxypeptidase
dipeptidyl carboxypeptidase I
endothelial cell peptidyl dipeptidase
kininase II
peptidase P
peptidyl dipeptidase A
peptidyl dipeptidase I
peptidyl dipeptidase-4
peptidyl dipeptide hydrolase
peptidyl-dipeptide hydrolase
peptidyldipeptide hydrolase
DCP
PDH
angiotensin I-converting enzyme
angiotensin converting enzyme
carboxycathepsin
dipeptidase
dipeptide hydrolase [ambiguous]
dipeptidyl carboxypeptidase
dipeptidyl carboxypeptidase I
endothelial cell peptidyl dipeptidase
kininase II
peptidase P
peptidyl dipeptidase A
peptidyl dipeptidase I
peptidyl dipeptidase-4
peptidyl dipeptide hydrolase
peptidyl-dipeptide hydrolase
peptidyldipeptide hydrolase
Systematic name:
-
Reaction
-
angiotensin IName origin: UniProt - CHECKED (C)Formula: C62H89N17O14
Charge: 0ChEBI compound status: CHECKED (C)H2OName origin: UniProt - CHECKED (C)Formula: H2O
Charge: 0ChEBI compound status: CHECKED (C)=angiotensin IIName origin: UniProt - CHECKED (C)Formula: C50H71N13O12
Charge: 0ChEBI compound status: CHECKED (C)
Cofactor
Comments:
A Cl−-dependent, zinc glycoprotein that is generally membrane-bound. A potent inhibitor is captopril. Important in elevation of blood pressure, through formation of angiotensin II (vasoconstrictor) and destruction of bradykinin (vasodilator). Two molecular forms exist in mammalian tissues, a widely-distributed somatic form of 150- to 180-kDa that contains two non-identical catalytic sites, and a testicular form of 90- to 100-kDa that contains only a single catalytic site. Type example of peptidase family M2.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
MEROPS
,
UniPathway
Protein domains and families:
PROSITE:PDOC00129
Gene Ontology:
GO:0004246
CAS Registry Number:
9015-82-1
References
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Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning.Proc. Natl. Acad. Sci. USA 85 : 9386-9390 (1988). [PMID: 89071703]
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Molecular cloning of human testicular angiotensin-converting enzyme: the testis enzyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme.Proc. Natl. Acad. Sci. USA 86 : 7741-7745 (1989). [PMID: 2554286]
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The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors.J. Biol. Chem. 267 : 13398-13405 (1992). [PMID: 1320019]
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Peptidyl dipeptidase A: angiotensin I-converting enzyme.Methods Enzymol. 248 : 283-305 (1995). [PMID: 7674927]
[EC 3.4.15.1 created 1972, modified 1981, modified 1989, modified 1996, modified 2011]