EC - Dipeptidyl-peptidase IV

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IntEnz Enzyme Nomenclature


Accepted name:
dipeptidyl-peptidase IV
Other names:
Gly-Pro naphthylamidase
T cell triggering molecule Tp103
X-prolyl dipeptidyl aminopeptidase
amino acyl-prolyl dipeptidyl aminopeptidase
dipeptidyl aminopeptidase IV
dipeptidyl peptidase IV
dipeptidyl-aminopeptidase IV
dipeptidyl-peptide hydrolase
glycoprotein GP110
glycylproline aminopeptidase
glycylprolyl aminopeptidase
glycylprolyl dipeptidylaminopeptidase
leukocyte antigen CD26
lymphocyte antigen CD26
pep X
postproline dipeptidyl aminopeptidase IV
Systematic name:



A homodimer. An integral protein of the plasma membrane of lymphocytes and other mammalian cells, in peptidase family S9 (prolyl oligopeptidase family). The reaction is similar to that of the unrelated Xaa-Pro dipeptidyl-peptidase of lactococci.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00587
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004274
CAS Registry Number: 54249-88-6
UniProtKB/Swiss-Prot: (76) [show] [UniProt]


  1. Misumi, Y., Hayashi, Y., Arakawa, F. and Ikehara, Y.
    Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface.
    Biochim. Biophys. Acta 1131: 333-336 (1992). [PMID: 1352704]
  2. David, F., Bernard, A.-M., Pierres, M. and Marguet, D.
    Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26). A member of a novel family of nonclassical serine hydrolases.
    J. Biol. Chem. 268: 17247-17252 (1993). [PMID: 8102366]
  3. Ikehara, Y., Ogata, S. and Misumi, Y.
    Dipeptidyl-peptidase IV from rat liver.
    Methods Enzymol. 244: 215-227 (1994). [PMID: 7845210]

[EC created 1981, modified 1996]