EC - Xaa-Pro aminopeptidase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
Xaa-Pro aminopeptidase
Other names:
X-Pro aminopeptidase
aminoacylproline aminopeptidase
aminopeptidase P
proline aminopeptidase
Systematic name:




A Mn2+-dependent, generally membrane-bound enzyme present in both mammalian and bacterial cells. In peptidase family M24 (methionyl aminopeptidase family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00417
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008451
CAS Registry Number: 37288-66-7
UniProtKB/Swiss-Prot: (150) [show] [UniProt]


  1. Yaron, A. and Mlynar, D.
    Biochem. Biophys. Res. Commun. 32: 658-663 (1968). [PMID: 4878817]
  2. Yaron, A. and Berger, A.
    Methods Enzymol. 19: 522-534 (1970).
  3. Fleminger, G., Carmel, A. and Yaron, A.
    Fluorogenic substrates for bacterial aminopeptidase P and its analogs detected in human serum and calf lung.
    Eur. J. Biochem. 125: 609-615 (1983). [PMID: 6749499]
  4. Orawski, A.T., Susz, J.P. and Simmons, W.H.
    Aminopeptidase-P from bovine lung - solubilization, properties, potential role in bradykinin degradation.
    Mol. Cell. Biochem. 75: 123-132 (1987). [PMID: 3627107]
  5. Hooper, N.M., Hryszko, J. and Turner, A.J.
    Purification and characterization of pig kidney aminopeptidase P.
    Biochem. J. 267: 509-515 (1990). [PMID: 2139778]

[EC created 1972]