EC 3.4.11.6 - Aminopeptidase B

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IntEnz Enzyme Nomenclature
EC 3.4.11.6

Names

Accepted name:
aminopeptidase B
Other names:
L-arginine aminopeptidase
Cl--activated arginine aminopeptidase
arginine aminopeptidase
arginyl aminopeptidase
arylamidase II
cytosol aminopeptidase IV
Systematic name:
-

Reaction

Cofactor

Comments:

Cytosolic or membrane-associated enzyme from mammalian tissues, activated by chloride ions and low concentrations of thiol compounds. This is one of the activities of the bifunctional enzyme EC 3.3.2.6 (membrane alanyl aminopeptidase family) [4,5].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
Gene Ontology: GO:0030601
CAS Registry Number: 9073-92-1
UniProtKB/Swiss-Prot:

References

  1. Gainer, H., Russell, J.T. and Loh, Y.P.
    An aminopeptidase activity in bovine pituitary secretory vesicles that cleaves the N-terminal arginine from beta-lipotropin(60-65).
    FEBS Lett. 175: 135-139 (1984). [PMID: 6434344]
  2. Belhacène, N., Mari, B., Rossi, B. and Auberger, P.
    Characterization and purification of T lymphocyte aminopeptidase B: a putative marker of T cell activation.
    Eur. J. Immunol. 23: 1948-1955 (1993). [PMID: 8344358]
  3. Cadel, S., Pierotti, A.R., Foulon, T., Créminon, C., Barré, N., Segrétain, D. and Cohen, P.
    Aminopeptidase-B in the rat testes: Isolation, functional properties and cellular localization in the seminiferous tubules.
    Mol. Cell. Endocrinol. 110: 149-160 (1995). [PMID: 7672445]
  4. Fukasawa, K.M., Fukasawa, K., Kanai, M., Fujii, S. and Harada, M.
    Molecular cloning and expression of rat liver aminopeptidase B.
    J. Biol. Chem. 271: 30731-30735 (1996). [PMID: 8940051]
  5. Cadel, S., Foulon, T., Viron, A., Balogh, A., Midol-Monnet, S., Noel, N. and Cohen, P.
    Aminopeptidase B from the rat testis is a bifunctional enzyme structually related to leukotriene-A4 hydrolase.
    Proc. Natl. Acad. Sci. USA 94: 2963-2968 (1997). [PMID: 5798121]
  6. Orning, L., Gierse, J.K. and Fitzpatrick, F.A.
    The bifunctional enzyme leukotriene-A4 hydrolase is an arginine aminopeptidase of high efficiency and specificity.
    J. Biol. Chem. 269: 11269-11273 (1994). [PMID: 8157657]

[EC 3.4.11.6 created 1972, modified 1997]