EC 3.4.11.3 - Cystinyl aminopeptidase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 3.4.11.3
Names
Accepted name:
cystinyl aminopeptidase
Other
names:
L-cystine aminopeptidase
cystine aminopeptidase
cystyl-aminopeptidase
oxytocin peptidase
oxytocinase
vasopresssinase
cystine aminopeptidase
cystyl-aminopeptidase
oxytocin peptidase
oxytocinase
vasopresssinase
Systematic name:
-
Reaction
- Release of an N-terminal amino acid, CysXaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however.
Cofactor
Comments:
A zinc-containing sialoglycoprotein in peptidase family M1 (membrane alanyl aminopeptidase family).
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
MEROPS
,
UniPathway
CAS Registry Number:
9031-41-8
UniProtKB/Swiss-Prot:
References
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Biochemical studies on oxytocin and oxytocinase.Acta Pharm. Suec. 4 : 81-96 (1967). [PMID: 6041057]
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Degradation of oxytocin, lysine vasopressin, angiotensin II, and angiotensin II amide by oxytocinase (cystine aminopeptidase).Acta Pharm. Suec. 4 : 65-76 (1967). [PMID: 4292447]
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Studies on human serum aminopeptidase. Some properties of oxytocinase, human serum aminopeptidase A and leucine aminopeptidase and their purification from retroplacental serum.Acta Pharm. Suec. 7 : 75-86 (1970). [PMID: 5421622]
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Purification and properties of oxytocinase, a metalloenzyme.Biochem. Int. 2 : 173-179 (1981).
[EC 3.4.11.3 created 1972]