EC 3.4.11.21 - Aspartyl aminopeptidase

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IntEnz Enzyme Nomenclature
EC 3.4.11.21

Names

Accepted name:
aspartyl aminopeptidase
Systematic name:

Reaction

Comments:

Aminoacyl-arylamides are poor substrates. This is an abundant cytosolic enzyme in mammalian cells, in peptidase family M18 of aminopeptidase I.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0042576
UniProtKB/Swiss-Prot: (10) [show] [UniProt]

References

  1. Kelly, J.A., Neidle, E.L. and Neidle, A.
    An aminopeptidase from mouse brain cytosol that cleaves N-terminal acidic amino acid residues.
    J. Neurochem. 40: 1727-1734 (1983). [PMID: 6854330]
  2. Wilk, S., Wilk, E. and Magnusson, R.P.
    Purification, characterization and cloning of a cytosolic aspartyl aminopeptidase.
    J. Biol. Chem. 273: 15961-15970 (1998). [PMID: 9632644]

[EC 3.4.11.21 created 2000]