IntEnz

EC 3.4.11.2 - Membrane alanyl aminopeptidase

IntEnz Enzyme Nomenclature
EC 3.4.11.2

Names

Reaction

• Release of an N-terminal amino acid, XaaYaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.

Cofactor

• Zn²⁺

Comments:

A zinc enzyme, not activated by heavy metal ions. Type example of peptidase family M1. Formerly EC 3.4.1.2.

Links to other databases

References

1. Wachsmuth, D., Fritze, I. and Pfleiderer, G.
   An aminopeptidase occurring in pig kidney. I. An improved method of preparation. Physical and enzymatic properties.
   Biochemistry 5 : 169-174 (1966). [PMID: 5938934]
2. Kim, Y.S. and Brophy, E.J.
   Rat intestinal brush border membrane peptidases. I. Solubilization, purification of two different forms of enzyme.
   J. Biol. Chem. 251 : 3199-3205 (1976). [PMID: 931983]
3. Gray, G.M. and Santiago, N.A.
   Intestinal surface amino-oligopeptidases. I. Isolation of two weight isomers and their subunits from rat brush border.
   J. Biol. Chem. 252 : 4922-4928 (1977). [PMID: 873921]
4. Sjöström, H., Norén, O., Jeppesen, L., Staun, M., Svensson, B. and Christiansen, L.
   Purification of different amphiphilic forms of a microvillus aminopeptidase from pig small intestine using immunoadsorbent chromatography.
   Eur. J. Biochem. 88 : 503-511 (1978). [PMID: 357150]
5. Ferracci, H. and Maroux, S.
   Rabbit intestinal aminopeptidase N. Purification and molecular properties.
   Biochim. Biophys. Acta. 599 : 448-463 (1980). [PMID: 6105876]

[EC 3.4.11.2 created 1961 as EC 3.4.1.2, transferred 1972 to EC 3.4.11.2 (EC 3.4.13.6 created 1961 as EC 3.4.3.5, transferred 1972 to EC 3.4.13.6, incorporated 1997)]