EC - Aminopeptidase Y

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IntEnz Enzyme Nomenclature


Accepted name:
aminopeptidase Y
Other names:
aminopeptidase (cobalt-activated)
aminopeptidase Co
lysyl aminopeptidase
Systematic name:




Requires Co2+; inhibited by Zn2+ and Mn2+. An enzyme best known from Saccharomyces cerevisiae that hydrolyses Lys-NHPhNO2 and, more slowly, Arg-NHPhNO2. Type example of peptidase family M28.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB


  1. Achstetter, T., Ehmann, C. and Wolf, D.H.
    Aminopeptidase Co, a new yeast peptidase.
    Biochem. Biophys. Res. Commun. 109 : 341-347 (1982). [PMID: 6758786]
  2. Yasuhara, T., Nakai, T. and Ohashi, A.
    Aminopeptidase Y, a new aminopeptidase from Saccharomyces cerevisiae. Purification, properties, localization, and processing by protease B.
    J. Biol. Chem. 269 : 13644-13650 (1994). [PMID: 8175799]
  3. Nishizawa, M., Yasuhara, T., Nakai, T., Fujiki, Y. and Ohashi, A.
    Molecular cloning of the aminopeptidase Y gene of Saccharomyces cerevisiae. Sequence analysis and gene disruption of a new aminopeptidase.
    J. Biol. Chem. 269 : 13651-13655 (1994). [PMID: 8175800]

[EC created 1989, modified 1997]