IntEnz

EC 3.4.11.1 - Leucyl aminopeptidase

IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 3.4.11.1

Names

Accepted name:

leucyl aminopeptidase

Other names:

L-leucine aminopeptidase
FTBL proteins
aminopeptidase I
aminopeptidase II
aminopeptidase III
cathepsin III
cytosol aminopeptidase
leucinamide aminopeptidase
leucinaminopeptidase
leucine aminopeptidase
leucyl peptidase
peptidase S
proteinates FTBL

Systematic name:

Reaction

Release of an N-terminal amino acid, XaaYaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolysed, but rates on arylamides are exceedingly low.

Cofactor

Zn²⁺

Comments:

A zinc enzyme isolated from pig kidney and cattle lens; activated by heavy metal ions. Type example of peptidase family M17. Formerly EC 3.4.1.1.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , NIST 74 , UniPathway

Protein domains and families: PROSITE:PDOC00548

Structural data: CSA , EC2PDB

Gene Ontology: GO:0004178

CAS Registry Numbers: 9001-61-0 90119-07-6

UniProtKB/Swiss-Prot: (443) [show] [UniProt]

References

Himmelhoch, S.R.

Leucine aminopeptidase from swine kidney.

Methods Enzymol. 19 : 508-513 (1970).
Delange, R.J. and Smith, E.L.

Leucine aminopeptidase and other N-terminal exopeptidases.

In: Boyer, P.D. (Ed.) The Enzymes , 3rd ed. vol. 3 , Academic Press , New York , 1971 , 88-118
van Loon-Klaasen, L.A.H., Cuypers, H.T., van Westreenen, H., de Jong, W.W. and Bloemendal, H.

The primary structure of bovine lens leucine aminopeptidase. Complete amino acid sequence of the N-terminal cyanogen bromide fragment and site limited tryptic digestion.

Biochem. Biophys. Res. Commun. 95 : 334-341 (1980). [PMID: 7417261]

[EC 3.4.11.1 created 1961 as EC 3.4.1.1, transferred 1972 to EC 3.4.11.1]

EC 3 - Hydrolases

EC 3.4 - Acting on peptide bonds (peptidases)