EC 3.3.2.7 - Hepoxilin-epoxide hydrolase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 3.3.2.7

Names

Accepted name:
hepoxilin-epoxide hydrolase
Other names:
hepoxilin epoxide hydrolase
hepoxylin hydrolase
hepoxilin A3 hydrolase
Systematic name:
(5Z,9E,14Z)-(8ξ,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate hydrolase

Reaction

Comments:

Converts hepoxilin A3 into trioxilin A3. Highly specific for the substrate, having only slight activity with other epoxides such as leukotriene A4 and styrene oxide [2]. Hepoxilin A3 is an hydroxy-epoxide derivative of arachidonic acid that is formed via the 12-lipoxygenase pathway [2]. It is probable that this enzyme plays a modulatory role in inflammation, vascular physiology, systemic glucose metabolism and neurological function [4]. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol 5,6-oxide hydrolase) [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047977
CAS Registry Number: 122096-98-4

References

  1. Pace-Asciak, C.R.
    Formation and metabolism of hepoxilin A3 by the rat brain.
    Biochem. Biophys. Res. Commun. 151: 493-498 (1988). [PMID: 3348791]
  2. Pace-Asciak, C.R. and Lee, W.-S.
    Purification of hepoxilin epoxide hydrolase from rat liver.
    J. Biol. Chem. 264: 9310-9313 (1989). [PMID: 2722835]
  3. Fretland, A.J. and Omiecinski, C.J.
    Epoxide hydrolases: biochemistry and molecular biology.
    Chem. Biol. Interact. 129: 41-59 (2000). [PMID: 11154734]
  4. Newman, J.W., Morisseau, C. and Hammock, B.D.
    Epoxide hydrolases: their roles and interactions with lipid metabolism.
    Prog. Lipid Res. 44: 1-51 (2005). [PMID: 15748653]

[EC 3.3.2.7 created 1992, modified 2006]