EC - trans-2,3-dihydro-3-hydroxyanthranilic acid synthase

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IntEnz Enzyme Nomenclature


Accepted name:
trans-2,3-dihydro-3-hydroxyanthranilic acid synthase
Other names:
isochorismatase [ambiguous]
phzD (gene name)
Systematic name:
(2S)-2-amino-4-deoxychorismate pyruvate-hydrolase



Isolated from the bacterium Pseudomonas aeruginosa. Involved in phenazine biosynthesis.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Mavrodi, D. V., Bonsall, R. F., Delaney, S. M., Soule, M. J., Phillips, G., Thomashow, L. S.
    Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1.
    J. Bacteriol. 183: 6454-6465 (2001). [PMID: 11591691]
  2. Parsons, J. F., Calabrese, K., Eisenstein, E., Ladner, J. E.
    Structure and mechanism of Pseudomonas aeruginosa PhzD, an isochorismatase from the phenazine biosynthetic pathway.
    Biochemistry 42: 5684-5693 (2003). [PMID: 12741825]

[EC created 2016]