EC 3.3.2.11 - Cholesterol-5,6-oxide hydrolase

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IntEnz Enzyme Nomenclature
EC 3.3.2.11

Names

Accepted name:
cholesterol-5,6-oxide hydrolase
Other names:
cholesterol-epoxide hydrolase
ChEH
Systematic name:
5,6α-epoxy-5α-cholestan-3β-ol hydrolase

Reactions

Comments:

The enzyme appears to work equally well with both diastereoisomers of cholesterol 5,6-epoxide [3]. The product is a competitive inhibitor of the reaction. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol 5,6-oxide hydrolase) [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033963
UniProtKB/Swiss-Prot:

References

  1. Levin, W., Michaud, D.P., Thomas, P.E. and Jerina, D.M.
    Distinct rat hepatic microsomal epoxide hydrolases catalyze the hydration of cholesterol 5,6α-oxide and certain xenobiotic alkene and arene oxides.
    Arch. Biochem. Biophys. 220: 485-494 (1983). [PMID: 6401984]
  2. Oesch, F., Timms, C.W., Walker, C.H., Guenthner, T.M., Sparrow, A., Watabe, T. and Wolf, C.R.
    Existence of multiple forms of microsomal epoxide hydrolases with radically different substrate specificities.
    Carcinogenesis 5: 7-9 (1984). [PMID: 6690087]
  3. Sevanian, A. and McLeod, L.L.
    Catalytic properties and inhibition of hepatic cholesterol-epoxide hydrolase.
    J. Biol. Chem. 261: 54-59 (1986). [PMID: 3941086]
  4. Fretland, A.J. and Omiecinski, C.J.
    Epoxide hydrolases: biochemistry and molecular biology.
    Chem. Biol. Interact. 129: 41-59 (2000). [PMID: 11154734]
  5. Newman, J.W., Morisseau, C. and Hammock, B.D.
    Epoxide hydrolases: their roles and interactions with lipid metabolism.
    Prog. Lipid Res. 44: 1-51 (2005). [PMID: 15748653]

[EC 3.3.2.11 created 2006]