EC 3.2.2.9 - Adenosylhomocysteine nucleosidase
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IntEnz Enzyme Nomenclature
EC 3.2.2.9
Names
Accepted name:
adenosylhomocysteine nucleosidase
Other
names:
5'-methyladenosine nucleosidase
S-adenosylhomocysteine hydrolase [ambiguous]
S-adenosylhomocysteine nucleosidase
S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase
AdoHcy/MTA nucleosidase
S-adenosylhomocysteine hydrolase [ambiguous]
S-adenosylhomocysteine nucleosidase
S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase
AdoHcy/MTA nucleosidase
Systematic name:
S-adenosyl-L-homocysteine homocysteinylribohydrolase
Reactions
- (1) S-adenosyl-L-homocysteine + H2O = S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
- (2) 5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine
- (3) S-methyl-5'-thioadenosine + H2O = 5-(methylsulfanyl)-D-ribose + adenine
Comments:
This enzyme, found in bacteria and plants, acts on three different substrates. It is involved in the S-adenosyl-L-methionine (SAM, AdoMet) cycle, which recycles S-adenosyl-L-homocysteine back to SAM, and in salvage pathways for 5'-deoxyadenosine and S-methyl-5'-thioadenosine, which are produced from SAM during the action of many enzymes. Cf. The plant enzyme EC 3.2.2.16.
Links to other databases
Gene Ontology:
GO:0008782
CAS Registry Number:
9055-10-1
References
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A hydrolytic nucleosidase acting on S-adenosylhomocysteine and on 5-methylthioadenosine.J. Biol. Chem. 237 : 3737-3741 (1962).
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Kinetic properties and the effect of substrate analogues on 5'-methylthioadenosine nucleosidase from Escherichia coli.Biochim. Biophys. Acta 438 : 487-494 (1976). [PMID: 782530]
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Characterization of recombinant Eschericha coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase: analysis of enzymatic activity and substrate specificity.Biochem. Biophys. Res. Commun. 228 : 724-732 (1996). [PMID: 8941345]
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Biochemical and structural characterization of 5'-methylthioadenosine nucleosidases from Arabidopsis thaliana.Biochem. Biophys. Res. Commun. 381 : 619-624 (2009). [PMID: 19249293]
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Biotin synthase exhibits burst kinetics and multiple turnovers in the absence of inhibition by products and product-related biomolecules.Biochemistry 49 : 9985-9996 (2010). [PMID: 20961145]
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A bifunctional salvage pathway for two distinct S-adenosylmethionine by-products that is widespread in bacteria, including pathogenic Escherichia coli.Mol. Microbiol. (2020). [PMID: 31950558]
[EC 3.2.2.9 created 1972, modified 2004, modified 2020]