IntEnz

EC 3.2.2.9 - Adenosylhomocysteine nucleosidase

IntEnz Enzyme Nomenclature
EC 3.2.2.9

Names

Reactions

• 17805 [IUBMB]
  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  S-adenosyl-L-homocysteine

  S-adenosyl-L-homocysteine

  Name origin: UniProt - CHECKED (C)

  CHEBI:57856

  Formula: C14H20N6O5S
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  adenine

  adenine

  Name origin: UniProt - CHECKED (C)

  CHEBI:16708

  Formula: C5H5N5
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  S-(5-deoxy-D-ribos-5-yl)-L-homocysteine

  S-(5-deoxy-D-ribos-5-yl)-L-homocysteine

  Name origin: UniProt - CHECKED (C)

  CHEBI:58195

  Formula: C9H17NO6S
  Charge: 0

  ChEBI compound status: CHECKED (C)

  
• 13617
  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  S-methyl-5'-thioadenosine

  S-methyl-5'-thioadenosine

  Name origin: UniProt - CHECKED (C)

  CHEBI:17509

  Formula: C11H15N5O3S
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  adenine

  adenine

  Name origin: UniProt - CHECKED (C)

  CHEBI:16708

  Formula: C5H5N5
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  S-methyl-5-thio-D-ribose

  S-methyl-5-thio-D-ribose

  Name origin: UniProt - CHECKED (C)

  CHEBI:16895

  Formula: C6H12O4S
  Charge: 0

  ChEBI compound status: CHECKED (C)

  
• 29859
  5'-deoxyadenosine

  5'-deoxyadenosine

  Name origin: UniProt - CHECKED (C)

  CHEBI:17319

  Formula: C10H13N5O3
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  5-deoxy-D-ribose

  5-deoxy-D-ribose

  Name origin: UniProt - CHECKED (C)

  CHEBI:62012

  Formula: C5H10O4
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  adenine

  adenine

  Name origin: UniProt - CHECKED (C)

  CHEBI:16708

  Formula: C5H5N5
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

Comments:

Also acts on S-methyl-5'-thioadenosine to give adenine and S-methyl-5-thioribose (cf. EC 3.2.2.16, methylthioadenosine nucleosidase).

Links to other databases

References

1. Duerre, J.A.
   A hydrolytic nucleosidase acting on S-adenosylhomocysteine and on 5-methylthioadenosine.
   J. Biol. Chem. 237: 3737-3741 (1962).
2. Ferro, A.J., Barrett, A. and Shapiro, S.K.
   Kinetic properties and the effect of substrate analogues on 5'-methylthioadenosine nucleosidase from Escherichia coli.
   Biochim. Biophys. Acta 438: 487-494 (1976). [PMID: 782530]
3. Choi-Rhee, E., Cronan, J. E.
   A nucleosidase required for in vivo function of the S-adenosyl-L-methionine radical enzyme, biotin synthase.
   Chem. Biol. 12: 589-593 (2005). [PMID: 15911379]
4. Farrar, C. E., Siu, K. K., Howell, P. L., Jarrett, J. T.
   Biotin synthase exhibits burst kinetics and multiple turnovers in the absence of inhibition by products and product-related biomolecules.
   Biochemistry 49: 9985-9996 (2010). [PMID: 20961145]

[EC 3.2.2.9 created 1972, modified 2004]