EC - Ribosylpyrimidine nucleosidase

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IntEnz Enzyme Nomenclature


Accepted name:
ribosylpyrimidine nucleosidase
Other names:
N-ribosylpyrimidine nucleosidase
N-ribosylpyrimidine ribohydrolase
pyrimidine nucleosidase
nucleoside ribohydrolase
Systematic name:
pyrimidine-nucleoside ribohydrolase



Also hydrolyses purine D-ribonucleosides, but more slowly. 2'-, 3'- and 5'-deoxynucleosides are not substrates [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050263
CAS Registry Number: 37288-60-1
UniProtKB/Swiss-Prot: (28) [show] [UniProt]


  1. Terada, M., Tatibana, M. and Hayaishi, O.
    Preparation and properties of nucleoside hydrolase from Pseudomonas fluorescens.
    J. Biol. Chem. 242 : 5578-5585 (1967). [PMID: 12325375]
  2. Petersen, C. and Møller, L.B.
    The RihA, RihB, and RihC ribonucleoside hydrolases of Escherichia coli. Substrate specificity, gene expression, and regulation.
    J. Biol. Chem. 276 : 884-894 (2001). [PMID: 11027694]
  3. Giabbai, B. and Degano, M.
    Cloning, purification, crystallization and X-ray analysis of the Escherichia coli pyrimidine nucleoside hydrolase YeiK.
    Acta Crystallogr. D Biol. Crystallogr. 60 : 524-527 (2004). [PMID: 14993681]
  4. Giabbai, B. and Degano, M.
    Crystal structure to 1.7 Å of the Escherichia coli pyrimidine nucleoside hydrolase YeiK, a novel candidate for cancer gene therapy.
    Structure 12 : 739-749 (2004). [PMID: 15130467]

[EC created 1972]