EC 3.2.2.29 - Thymine-DNA glycosylase
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IntEnz Enzyme Nomenclature
EC 3.2.2.29
Names
Accepted name:
thymine-DNA glycosylase
Other
names:
mismatch-specific thymine-DNA glycosylase
mismatch-specific thymine-DNA N-glycosylase
hTDG
hsTDG
TDG
thymine DNA glycosylase
G/T glycosylase
uracil/thymine DNA glycosylase
T:G mismatch-specific thymidine-DNA glycosylase
G:T mismatch-specific thymine DNA-glycosylase
mismatch-specific thymine-DNA N-glycosylase
hTDG
hsTDG
TDG
thymine DNA glycosylase
G/T glycosylase
uracil/thymine DNA glycosylase
T:G mismatch-specific thymidine-DNA glycosylase
G:T mismatch-specific thymine DNA-glycosylase
Systematic name:
thymine-DNA deoxyribohydrolase (thymine-releasing)
Reaction
- Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine
Comments:
Thymine-DNA glycosylase is part of the DNA-repair machinery. Thymine removal is fastest when it is from a G/T mismatch with a 5'-flanking C/G pair. The glycosylase removes uracil from G/U, C/U, and T/U base pairs faster than it removes thymine from G/T [3].
Links to other databases
UniProtKB/Swiss-Prot:
MIG_AERPE
MIG_METTF
MIG_PYRAE
TDG-2_MOUSE
TDG_HUMAN
TDG_MOUSE
References
-
Thymine-DNA glycosylase and G to A transition mutations at CpG sites.Mutat. Res. 462 : 137-147 (2000). [PMID: 10767625]
-
The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells.J. Biol. Chem. 268 : 21218-21224 (1993). [PMID: 8407958]
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Kinetics of the action of thymine DNA glycosylase.J. Biol. Chem. 273 : 20007-20014 (1998). [PMID: 9685338]
[EC 3.2.2.29 created 2009]