EC 3.2.2.29 - Thymine-DNA glycosylase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 3.2.2.29

Names

Accepted name:
thymine-DNA glycosylase
Other names:
mismatch-specific thymine-DNA glycosylase
mismatch-specific thymine-DNA N-glycosylase
hTDG
hsTDG
TDG
thymine DNA glycosylase
G/T glycosylase
uracil/thymine DNA glycosylase
T:G mismatch-specific thymidine-DNA glycosylase
G:T mismatch-specific thymine DNA-glycosylase
Systematic name:
thymine-DNA deoxyribohydrolase (thymine-releasing)

Reaction

Comments:

Thymine-DNA glycosylase is part of the DNA-repair machinery. Thymine removal is fastest when it is from a G/T mismatch with a 5'-flanking C/G pair. The glycosylase removes uracil from G/U, C/U, and T/U base pairs faster than it removes thymine from G/T [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Waters, T. R., Swann, P. F.
    Thymine-DNA glycosylase and G to A transition mutations at CpG sites.
    Mutat. Res. 462: 137-147 (2000). [PMID: 10767625]
  2. Neddermann, P., Jiricny, J.
    The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells.
    J. Biol. Chem. 268: 21218-21224 (1993). [PMID: 8407958]
  3. Waters, T. R., Swann, P. F.
    Kinetics of the action of thymine DNA glycosylase.
    J. Biol. Chem. 273: 20007-20014 (1998). [PMID: 9685338]

[EC 3.2.2.29 created 2009]