EC - DNA-3-methyladenine glycosylase I

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IntEnz Enzyme Nomenclature


Accepted name:
DNA-3-methyladenine glycosylase I
Other names:
3-methyladenine DNA glycosylase I
deoxyribonucleate 3-methyladenine glycosidase I
Systematic name:
alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)



Involved in the removal of alkylated bases from DNA in Escherichia coli (cf. EC methylated-DNA-[protein]-cysteine S-methyltransferase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00447
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008725


  1. Evensen, G. and Seeberg, E.
    Adaptation to alkylation resistance involves the induction of a DNA glycosylase.
    Nature 296 : 773-775 (1982). [PMID: 7040984]
  2. Karran, P., Hjelmgren, T. and Lindahl, T.
    Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents.
    Nature 296 : 770-773 (1982). [PMID: 7040983]
  3. Thomas, L., Yang, C.-H. and Goldthwait, D.A.
    Two DNA glycosylases in Escherichia coli which release primarily 3-methyladenine.
    Biochemistry 21 : 1162-1169 (1982). [PMID: 7041972]

[EC created 1990, modified 2000]