EC - Methylthioadenosine nucleosidase

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IntEnz Enzyme Nomenclature


Accepted name:
methylthioadenosine nucleosidase
Other names:
5'-methylthioadenosine nucleosidase
MTA nucleosidase
MeSAdo nucleosidase
methylthioadenosine methylthioribohydrolase
Systematic name:
S-methyl-5'-thioadenosine adeninehyrolase



Unlike EC, this plant enzyme has little or no activity with S-adenosyl-L-homocysteine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008930
CAS Registry Number: 50812-28-7


  1. Guranowski, A.B., Chiang, P.K. and Cantoni, G.L.
    5'-Methylthioadenosine nucleosidase. Purification and characterization of the enzyme from Lupinus luteus seeds.
    Eur. J. Biochem. 114 : 293-299 (1981). [PMID: 6783408]
  2. Rzewuski, G., Cornell, K. A., Rooney, L., Burstenbinder, K., Wirtz, M., Hell, R., Sauter, M.
    OsMTN encodes a 5'-methylthioadenosine nucleosidase that is up-regulated during submergence-induced ethylene synthesis in rice (Oryza sativa L.).
    J. Exp. Bot. 58 : 1505-1514 (2007). [PMID: 17339651]
  3. Siu, K. K., Lee, J. E., Sufrin, J. R., Moffatt, B. A., McMillan, M., Cornell, K. A., Isom, C., Howell, P. L.
    Molecular determinants of substrate specificity in plant 5'-methylthioadenosine nucleosidases.
    J. Mol. Biol. 378 : 112-128 (2008). [PMID: 18342331]
  4. Park, E. Y., Choi, W. S., Oh, S. I., Kim, K. N., Shin, J. S., Song, H. K.
    Biochemical and structural characterization of 5'-methylthioadenosine nucleosidases from Arabidopsis thaliana.
    Biochem. Biophys. Res. Commun. 381 : 619-624 (2009). [PMID: 19249293]

[EC created 1983, modified 2003]