EC 3.2.2.14 - NMN nucleosidase

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IntEnz Enzyme Nomenclature
EC 3.2.2.14

Names

Accepted name:
NMN nucleosidase
Other names:
NMN glycohydrolase
NMNGhase
NMNase
nicotinamide mononucleotidase
nicotinamide mononucleotide nucleosidase
Systematic name:
nicotinamide-nucleotide phosphoribohydrolase

Reaction

Comments:

The enzyme is thought to participate in an NAD+-salvage pathway. In eukaryotic organisms this activity has been attributed to EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0019160
CAS Registry Number: 37237-49-3

References

  1. Andreoli, A.J., Okita, T.W., Bloom, R. and Grover, T.A.
    The pyridine nucleotide cycle: presence of a nicotinamide mononucleotide-specific glycohydrolase in Escherichia coli.
    Biochem. Biophys. Res. Commun. 49 : 264-269 (1972). [PMID: 4342726]
  2. Imai, T.
    Isolation and properties of a glycohydrolase specific for nicotinamide mononucleotide from Azotobacter vinelandii.
    J. Biochem. 85 : 887-899 (1979). [PMID: 457634]
  3. Imai, T.
    Properties of allosteric nicotinamide mononucleotide glycohydrolase from Azotobacter vinelandii: activation and inhibition.
    J. Biochem. 101 : 163-173 (1987). [PMID: 3571198]

[EC 3.2.2.14 created 1976]