EC 3.2.1.33 - Amylo-α-1,6-glucosidase

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IntEnz Enzyme Nomenclature
EC 3.2.1.33

Names

Accepted name:
amylo-α-1,6-glucosidase
Other names:
amylo-1,6-glucosidase
amylopectin 1,6-glucosidase
dextrin 6-α-D-glucosidase
dextrin-1,6-glucosidase
glycogen phosphorylase-limit dextrin α-1,6-glucohydrolase
Systematic name:
glycogen phosphorylase-limit dextrin 6-α-glucohydrolase

Reaction

Comments:

This enzyme hydrolyses an unsubstituted glucose unit linked by an α(1→6) bond to an α(1→4) glucose chain. The enzyme activity found in mammals and yeast is in a polypeptide chain containing two active centres. The other activity is similar to that of EC 2.4.1.25 (4-α-glucanotransferase), which acts on the glycogen phosphorylase limit dextrin chains to expose the single glucose residues, which the 6-α-glucosidase activity can then hydrolyse. Together, these two activities constitute the glycogen debranching system.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004135
CAS Registry Number: 9012-47-9
UniProtKB/Swiss-Prot:

References

  1. Brown, D.H. and Brown, B.I.
    Enzymes of glycogen debranching: Amylo-1,6-glucosidase (I) and oligo-1,4→1,4-glucanotransferase (II).
    Methods Enzymol. 8: 515-524 (1966).
  2. Lee, E.Y.C., Carter, J.H., Nielsen, L.D. and Fischer, E.H.
    Purification and properties of yeast amylo-1,6-glucosidase-oligo-1,4 leads to 1,4-glucantransferase.
    Biochemistry 9: 2347-2355 (1970). [PMID: 5424210]
  3. Nelson, T.E., Kolb, E. and Larner, J.
    Purification and properties of rabbit muscle amylo-1,6-glucosidase-oligo-1,4-1,4-transferase.
    Biochemistry 8: 1419-1428 (1969). [PMID: 5805288]

[EC 3.2.1.33 created 1965, modified 2000]