EC 3 - Hydrolases
EC 3.2 - Glycosylases
EC 3.2.1 - Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds
EC 3.2.1.28 - α,α-trehalase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 3.2.1.28
Names
Accepted name:
α,α-trehalase
Other
name:
trehalase
Systematic name:
α,α-trehalose glucohydrolase
Reaction
- alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose
Comments:
The enzyme is an anomer-inverting glucosidase that catalyses the hydrolysis of the α-glucosidic O-linkage of α,α-trehalose, releasing initially equimolar amounts of α- and β-D-glucose. It is widely distributed in microorganisms, plants, invertebrates and vertebrates.
Links to other databases
Protein domains and families:
PROSITE:PDOC00717
Gene Ontology:
GO:0004555
CAS Registry Number:
9025-52-9
References
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The preparation and properties of trehalase.J. Biol. Chem. 230 : 691-698 (1958). [PMID: 13525386]
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Trehalose und Hefe. II. Trehalasewirkung von Hefepräparaten.Biochem. Z. 291 : 61-69 (1937).
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Trehalase: stereocomplementary hydrolytic and glucosyl transfer reactions with alpha- and beta-D-glucosyl fluoride.Biochemistry 21 : 3090-3097 (1982). [PMID: 7104311]
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Catalytic reaction mechanism based on alpha-secondary deuterium isotope effects in hydrolysis of trehalose by European honeybee trehalase.Biosci. Biotechnol. Biochem. 73 : 2466-2473 (2009). [PMID: 19897915]
[EC 3.2.1.28 created 1961, modified 2012]