EC 3.2.1.28 - α,α-trehalase

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IntEnz Enzyme Nomenclature
EC 3.2.1.28

Names

Accepted name:
α,α-trehalase
Other name:
trehalase
Systematic name:
α,α-trehalose glucohydrolase

Reaction

Comments:

The enzyme is an anomer-inverting glucosidase that catalyses the hydrolysis of the α-glucosidic O-linkage of α,α-trehalose, releasing initially equimolar amounts of α- and β-D-glucose. It is widely distributed in microorganisms, plants, invertebrates and vertebrates.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00717
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004555
CAS Registry Number: 9025-52-9
UniProtKB/Swiss-Prot: (119) [show] [UniProt]

References

  1. Kalf, G.F. and Rieder, S.V.
    The preparation and properties of trehalase.
    J. Biol. Chem. 230 : 691-698 (1958). [PMID: 13525386]
  2. Myrbäck, K. and Örtenblad, B.
    Trehalose und Hefe. II. Trehalasewirkung von Hefepräparaten.
    Biochem. Z. 291 : 61-69 (1937).
  3. Hehre, E. J., Sawai, T., Brewer, C. F., Nakano, M., Kanda, T.
    Trehalase: stereocomplementary hydrolytic and glucosyl transfer reactions with alpha- and beta-D-glucosyl fluoride.
    Biochemistry 21 : 3090-3097 (1982). [PMID: 7104311]
  4. Mori, H., Lee, J. H., Okuyama, M., Nishimoto, M., Ohguchi, M., Kim, D., Kimura, A., Chiba, S.
    Catalytic reaction mechanism based on alpha-secondary deuterium isotope effects in hydrolysis of trehalose by European honeybee trehalase.
    Biosci. Biotechnol. Biochem. 73 : 2466-2473 (2009). [PMID: 19897915]

[EC 3.2.1.28 created 1961, modified 2012]