EC - Exo-chitinase (reducing end)

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IntEnz Enzyme Nomenclature


Accepted name:
exo-chitinase (reducing end)
Other name:
chiA (gene name)
Systematic name:
(1→4)-2-acetamido-2-deoxy-β-D-glucan diacetylchitobiohydrolase (reducing end)



The enzyme hydrolyses the second glycosidic (1→4) linkage from reducing ends of chitin and chitodextrin molecules, liberating N,N'-diacetylchitobiose disaccharides. cf. EC, exo-chitinase (non-reducing end).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Hult, E. L., Katouno, F., Uchiyama, T., Watanabe, T., Sugiyama, J.
    Molecular directionality in crystalline beta-chitin: hydrolysis by chitinases A and B from Serratia marcescens 2170.
    Biochem. J. 388: 851-856 (2005). [PMID: 15717865]
  2. Nakagawa, Y. S., Eijsink, V. G., Totani, K., Vaaje-Kolstad, G.
    Conversion of alpha-chitin substrates with varying particle size and crystallinity reveals substrate preferences of the chitinases and lytic polysaccharide monooxygenase of Serratia marcescens.
    J. Agric. Food Chem. 61: 11061-11066 (2013). [PMID: 24168426]
  3. Gutierrez-Roman, M. I., Dunn, M. F., Tinoco-Valencia, R., Holguin-Melendez, F., Huerta-Palacios, G., Guillen-Navarro, K.
    Potentiation of the synergistic activities of chitinases ChiA, ChiB and ChiC from Serratia marcescens CFFSUR-B2 by chitobiase (Chb) and chitin binding protein (CBP).
    World J. Microbiol. Biotechnol. 30: 33-42 (2014). [PMID: 23824666]
  4. Brurberg, M. B., Nes, I. F., Eijsink, V. G.
    Comparative studies of chitinases A and B from Serratia marcescens.
    Microbiology (Reading, Engl.) 142: 1581-1589 (1996). [PMID: 8757722]

[EC created 2017]