EC - Exo-chitinase (non-reducing end)

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IntEnz Enzyme Nomenclature


Accepted name:
exo-chitinase (non-reducing end)
Other name:
chiB (gene name)
Systematic name:
(1→4)-2-acetamido-2-deoxy-β-D-glucan diacetylchitobiohydrolase (non-reducing end)



The enzyme hydrolyses the second glycosidic (1→4) linkage from non-reducing ends of chitin and chitodextrin molecules, liberating N,N'-diacetylchitobiose disaccharides. cf. EC, exo-chitinase (reducing end).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Tanaka, T., Fukui, T., Imanaka, T.
    Different cleavage specificities of the dual catalytic domains in chitinase from the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1.
    J. Biol. Chem. 276: 35629-35635 (2001). [PMID: 11468293]
  2. Hult, E. L., Katouno, F., Uchiyama, T., Watanabe, T., Sugiyama, J.
    Molecular directionality in crystalline beta-chitin: hydrolysis by chitinases A and B from Serratia marcescens 2170.
    Biochem. J. 388: 851-856 (2005). [PMID: 15717865]
  3. Ohnuma, T., Numata, T., Osawa, T., Mizuhara, M., Lampela, O., Juffer, A. H., Skriver, K., Fukamizo, T.
    A class V chitinase from Arabidopsis thaliana: gene responses, enzymatic properties, and crystallographic analysis.
    Planta 234: 123-137 (2011). [PMID: 21390509]
  4. Gutierrez-Roman, M. I., Dunn, M. F., Tinoco-Valencia, R., Holguin-Melendez, F., Huerta-Palacios, G., Guillen-Navarro, K.
    Potentiation of the synergistic activities of chitinases ChiA, ChiB and ChiC from Serratia marcescens CFFSUR-B2 by chitobiase (Chb) and chitin binding protein (CBP).
    World J. Microbiol. Biotechnol. 30: 33-42 (2014). [PMID: 23824666]

[EC created 2017]