EC 3 - Hydrolases
EC 3.2 - Glycosylases
EC 3.2.1 - Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds
EC 3.2.1.20 - α-glucosidase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 3.2.1.20
Names
Accepted name:
α-glucosidase
Other
names:
α-1,4-glucosidase
α-D-glucosidase
α-glucopyranosidase
α-glucoside hydrolase
glucoinvertase
glucosidoinvertase
glucosidosucrase
maltase
maltase-glucoamylase
lysosomal α-glucosidase
acid maltase
α-D-glucosidase
α-glucopyranosidase
α-glucoside hydrolase
glucoinvertase
glucosidoinvertase
glucosidosucrase
maltase
maltase-glucoamylase
lysosomal α-glucosidase
acid maltase
Systematic name:
α-D-glucoside glucohydrolase
Reaction
- Hydrolysis of terminal, non-reducing (1right4)-linked alpha-D-glucose residues with release of alpha-D-glucose
Comments:
This single entry covers a group of enzymes whose specificity is directed mainly towards the exohydrolysis of 1,4-α-glucosidic linkages, and that hydrolyse oligosaccharides rapidly, relative to polysaccharide, which are hydrolysed relatively slowly, or not at all. The intestinal enzyme also hydrolyses polysaccharides, catalysing the reactions of EC 3.2.1.3 glucan 1,4-α-glucosidase and, more slowly, hydrolyses 1,6-α-D-glucose links.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
NIST 74
,
UniPathway
Protein domains and families:
PROSITE:PDOC00120
,
PROSITE:PDOC01027
CAS Registry Number:
9001-42-7
References
-
Further kinetic and structural characterization of the lysosomal α-D-glucoside glucohydrolase from cattle liver.Biochim. Biophys. Acta 212 : 470-477 (1970). [PMID: 5466143]
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Purification of rat intestinal maltase/glucoamylase and its anomalous dissociation either by heat or by low pH.Biochem. J. 173 : 553-563 (1978). [PMID: 29602]
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Other glucosidases.In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes , 2nd ed. vol. 4 , Academic Press , New York , 1960 , 369-378
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Purification of rabbit intestinal glucoamylase by affinity chromatography on Sephadex G-200.Indian J. Biochem. Biophys. 10 : 283-284 (1973). [PMID: 4792946]
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Amphiphilic pig intestinal microvillus maltase/glucoamylase. Structure and specificity.Eur. J. Biochem. 126 : 559-568 (1982). [PMID: 6814909]
[EC 3.2.1.20 created 1961]