EC 220.127.116.11 - α-mannan endo-1,2-α-mannanase
IntEnz Enzyme Nomenclature
- Hydrolysis of the terminal α-D-mannosyl-(1→3)-α-D-mannose disaccharide from α-D-mannosyl-(1→3)-α-D-mannosyl-(1→2)-α-D-mannosyl-(1→2)-α-D-mannosyl side chains in fungal cell wall α-mannans.
The enzyme, characterized from the gut bacteria Bacteroides thetaiotaomicron and Bacteroides xylanisolvens, can also catalyse the reaction of EC 18.104.22.168, glycoprotein endo-α-1,2-mannosidase.
Links to other databases
Structural and kinetic dissection of the endo-alpha-1,2-mannanase activity of bacterial GH99 glycoside hydrolases from Bacteroides spp.Chemistry 21: 1966-1977 (2015). [PMID: 25487964]
Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism.Nature 517: 165-169 (2015). [PMID: 25567280]
[EC 22.214.171.124 created 2016]