EC - α-mannan endo-1,2-α-mannanase

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IntEnz Enzyme Nomenclature


Accepted name:
α-mannan endo-1,2-α-mannanase
Systematic name:
α-mannan 1,2-[α-D-mannosyl-(1→3)-α-D--mannose] hydrolase



The enzyme, characterized from the gut bacteria Bacteroides thetaiotaomicron and Bacteroides xylanisolvens, can also catalyse the reaction of EC, glycoprotein endo-α-1,2-mannosidase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Hakki, Z., Thompson, A. J., Bellmaine, S., Speciale, G., Davies, G. J., Williams, S. J.
    Structural and kinetic dissection of the endo-alpha-1,2-mannanase activity of bacterial GH99 glycoside hydrolases from Bacteroides spp.
    Chemistry 21: 1966-1977 (2015). [PMID: 25487964]
  2. Cuskin, F., Lowe, E. C., Temple, M. J., Zhu, Y., Cameron, E. A., Pudlo, N. A., Porter, N. T., Urs, K., Thompson, A. J., Cartmell, A., Rogowski, A., Hamilton, B. S., Chen, R., Tolbert, T. J., Piens, K., Bracke, D., Vervecken, W., Hakki, Z., Speciale, G., Mun?z-Mun?z, J. L., Day, A., Pena, M. J., McLean, R., Suits, M. D., Boraston, A. B., Atherly, T., Ziemer, C. J., Williams, S. J., Davies, G. J., Abbott, D. W., Martens, E. C., Gilbert, H. J.
    Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism.
    Nature 517: 165-169 (2015). [PMID: 25567280]

[EC created 2016]