EC - α-neoagaro-oligosaccharide hydrolase

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IntEnz Enzyme Nomenclature


Accepted name:
α-neoagaro-oligosaccharide hydrolase
Other names:
α-neoagarooligosaccharide hydrolase
α-NAOS hydrolase
Systematic name:
α-neoagaro-oligosaccharide 3-glycohydrolase



When neoagarohexaose is used as a substrate, the oligosaccharide is cleaved at the non-reducing end to produce 3,6-anhydro-L-galactose and agaropentaose, which is further hydrolysed to agarobiose and agarotriose. With neoagarotetraose as substrate, the products are predominantly agarotriose and 3,6-anhydro-L-galactose. In Vibrio sp. the actions of EC, β-agarase and EC can be used to degrade agarose to 3,6-anhydro-L-galactose and D-galactose.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033954 , GO:0102253 , GO:0102256 , GO:0102254
CAS Registry Number: 60063-77-6


  1. Sugano, Y., Kodama, H., Terada, I., Yamazaki, Y. and Noma, M.
    Purification and characterization of a novel enzyme, α-neoagarooligosaccharide hydrolase (α-NAOS hydrolase), from a marine bacterium, Vibrio sp. strain JT0107.
    J. Bacteriol. 176: 6812-6818 (1994). [PMID: 7961439]

[EC created 2006]