EC 3.2.1.123 - Endoglycosylceramidase

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IntEnz Enzyme Nomenclature
EC 3.2.1.123

Names

Accepted name:
endoglycosylceramidase
Other names:
EGCase
endoglycoceramidase
glycosyl-N-acetyl-sphingosine 1,1-β-D-glucanohydrolase
endo-glucosylceramidase
oligoglycosylglucosylceramide glycohydrolase
Systematic name:
oligoglycosylglucosyl-(1↔1)-ceramide glycohydrolase

Reaction

Comments:

An enzyme from Rhodococcus sp. that degrades various acidic and neutral glycosphingolipids to oligosaccharides and ceramides, by cleaving a glucosyl bond. Does not act on monoglycosylceramides. cf. EC 3.2.1.62 glycosylceramidase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047876
UniProtKB/Swiss-Prot:

References

  1. Ito, M. and Yamagata, T.
    A novel glycosphingolipid-degrading enzyme cleaves the linkage between the oligosaccharide and ceramide of neutral and acidic glycosphingolipids.
    J. Biol. Chem. 261 : 14278-14282 (1986). [PMID: 3771534]

[EC 3.2.1.123 created 1989]