EC 3 - Hydrolases
EC 3.2 - Glycosylases
EC 3.2.1 - Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds
EC 3.2.1.108 - Lactase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 3.2.1.108
Names
Accepted name:
lactase
Other
name:
lactase-phlorizin hydrolase
Systematic name:
lactose galactohydrolase
Reaction
- lactose + H2O = D-galactose + D-glucose
Comments:
The enzyme from intestinal mucosa is isolated as a complex that also catalyses the reaction of EC 3.2.1.62 glycosylceramidase. cf. EC 3.2.1.33 amylo-α-1,6-glucosidase.
Links to other databases
Protein domains and families:
PROSITE:PDOC00495
Gene Ontology:
GO:0000016
UniProtKB/Swiss-Prot:
References
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Second enzyme defect in lactase deficiency. Lack of small-intestinal phlorizin-hydrolase.Eur. J. Clin. Invest. 2 : 326-331 (1972). [PMID: 5082068]
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Lactase-phlorizin hydrolase complex from monkey small intestine. Purification, properties and evidence for two catalytic sites.Biochim. Biophys. Acta 403 : 446-455 (1975). [PMID: 810166]
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The preparation of lactase and glucoamylase of rat small intestine.Biochim. Biophys. Acta 258 : 506-519 (1972). [PMID: 5010299]
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Further characterization of intestinal lactase/phlorizin hydrolase.Biochim. Biophys. Acta 707 : 89-97 (1982). [PMID: 6814489]
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Purification and characterization of amphiphilic lactase-phlorizin hydrolase from human small-intestine.Eur. J. Biochem. 114 : 653-661 (1981). [PMID: 6786877]
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Human small-intestinal β-galactosidases. Separation and characterization of one lactase and one hetero β-galactosidase.Biochem. J. 114 : 351-359 (1969). [PMID: 5822067]
[EC 3.2.1.108 created 1984]