EC - Lactase

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IntEnz Enzyme Nomenclature


Accepted name:
Other name:
lactase-phlorizin hydrolase
Systematic name:
lactose galactohydrolase



The enzyme from intestinal mucosa is isolated as a complex that also catalyses the reaction of EC glycosylceramidase. cf. EC amylo-α-1,6-glucosidase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00495
Structural data: CSA , EC2PDB
Gene Ontology: GO:0000016


  1. Lorenz-Meyer, H., Blum, A.L., Haemmerli, H.P. and Semenza, G.
    Second enzyme defect in lactase deficiency. Lack of small-intestinal phlorizin-hydrolase.
    Eur. J. Clin. Invest. 2 : 326-331 (1972). [PMID: 5082068]
  2. Ramaswamay, S. and Radhakrishnan, A.N.
    Lactase-phlorizin hydrolase complex from monkey small intestine. Purification, properties and evidence for two catalytic sites.
    Biochim. Biophys. Acta 403 : 446-455 (1975). [PMID: 810166]
  3. Schlegel-Haueter, S., Hore, P., Kerry, K.R. and Semenza, G.
    The preparation of lactase and glucoamylase of rat small intestine.
    Biochim. Biophys. Acta 258 : 506-519 (1972). [PMID: 5010299]
  4. Skovbjerg, H., Norén, O., Sjöström, H., Danielsen, E.M. and Enevoldsen, B.S.
    Further characterization of intestinal lactase/phlorizin hydrolase.
    Biochim. Biophys. Acta 707 : 89-97 (1982). [PMID: 6814489]
  5. Skovbjerg, H., Sjöström, H. and Norén, O.
    Purification and characterization of amphiphilic lactase-phlorizin hydrolase from human small-intestine.
    Eur. J. Biochem. 114 : 653-661 (1981). [PMID: 6786877]
  6. Asp, N.G., Dahlqvist, A. and Koldovsky, O.
    Human small-intestinal β-galactosidases. Separation and characterization of one lactase and one hetero β-galactosidase.
    Biochem. J. 114 : 351-359 (1969). [PMID: 5822067]

[EC created 1984]