EC - 2'-hydroxybiphenyl-2-sulfinate desulfinase

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IntEnz Enzyme Nomenclature


Accepted name:
2'-hydroxybiphenyl-2-sulfinate desulfinase
Other names:
gene dszB-encoded hydrolase
dibenzothiophene desulfurization enzyme B
2-(2-hydroxyphenyl) benzenesulfinate:H2O hydrolase
HBPSi desulfinase
2-(2-hydroxyphenyl) benzenesulfinate sulfohydrolase
HPBS desulfinase
2-(2-hydroxyphenyl)benzenesulfinate hydrolase
2-(2'-hydroxyphenyl)benzenesulfinate desulfinase
2-(2-hydroxyphenyl)benzenesulfinate desulfinase
Systematic name:
2'-hydroxybiphenyl-2-sulfinate sulfohydrolase




The enzyme from Rhodococcus sp. strain IGTS8 is encoded by the plasmid-encoded dibenzothiophene-desulfurization (dsz) operon. The enzyme has a narrow substrate specificity with biphenyl-2-sulfinate being the only other substrate known to date [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0018740


  1. Oldfield, C., Pogrebinsky, O., Simmonds, J., Ölson, E.S. and Kulpa, C.F.
    Elucidation of the metabolic pathway for dibenzothiophene desulfurization by Rhodococcus sp. strain IGTS8 (ATCC 53968).
    Microbiology 143 : 2961-2973 (1997). [PMID: 9308179]
  2. Nakayama, N., Matsubara, T., Ohshiro, T., Moroto, Y., Kawata, Y., Koizumi, K., Hirakawa, Y., Suzuki, M., Maruhashi, K., Izumi, Y. and Kurane, R.
    A novel enzyme, 2'-hydroxybiphenyl-2-sulfinate desulfinase (DszB), from a dibenzothiophene-desulfurizing bacterium Rhodococcus erythropolis KA2-5-1: gene overexpression and enzyme characterization.
    Biochim. Biophys. Acta 1598 : 122-130 (2002). [PMID: 12147352]
  3. Watkins, L.M., Rodriguez, R., Schneider, D., Broderick, R., Cruz, M., Chambers, R., Ruckman, E., Cody, M. and Mrachko, G.T.
    Purification and characterization of the aromatic desulfinase, 2-(2'-hydroxyphenyl)benzenesulfinate desulfinase.
    Arch. Biochem. Biophys. 415 : 14-23 (2003). [PMID: 12801508]

[EC created 2000 as EC, transferred 2005 to EC]