EC - UDP-sulfoquinovose synthase

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IntEnz Enzyme Nomenclature


Accepted name:
UDP-sulfoquinovose synthase
Other names:
UDPsulfoquinovose synthase
sulfite:UDP-glucose sulfotransferase
Systematic name:
UDP-6-sulfo-6-deoxyglucose sulfohydrolase




Requires NAD+, which appears to oxidize the substrate to UDP-4-dehydroglucose, which dehydrates to UDP-4-dehydro-6-deoxygluc-5-enose, to which sulfite can add; the reaction is completed when the substrate is rehydrogenated at C-4. The enzyme from Arabidopsis thaliana is specific for UDP-Glc and sulfite.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0046507


  1. Essigmann, B., Gler, S., Narang, R.A., Linke, D. and Benning, C.
    Phosphate availability affects the thylakoid lipid composition and the expression of SQD1, a gene required for sulfolipid biosynthesis in Arabidopsis thaliana.
    Proc. Natl. Acad. Sci. USA 95 : 1950-1955 (1998). [PMID: 9465123]
  2. Essigmann, B., Hespenheide, B.M., Kuhn, L.A. and Benning, C.
    Prediction of the active-site structure and NAD+ binding in SQD1, a protein essential for sulfolipid biosynthesis in Arabidopsis.
    Arch. Biochem. Biophys. 369 : 30-41 (1999). [PMID: 10462438]
  3. Mulichak, A.M., Theisen, M.J., Essigmann, B., Benning, C. and Garavito, R.M.
    Crystal structure of SQD1, an enzyme involved in the biosynthesis of the plant sulfolipid headgroup donor UDP-sulfoquinovose.
    Proc. Natl. Acad. Sci. USA 96 : 13097-13102 (1999). [PMID: 10557279]
  4. Sanda, S., Leustek, T., Theisen, M., Garavito, R.M. and Benning, C.
    Recombinant Arabidopsis SQD1 converts UDP-glucose and sulfite to the sulfolipid head group precursor UDP-sulfoquinovose in vitro.
    J. Biol. Chem. 276 : 3941-3946 (2001). [PMID: 11073956]

[EC created 2001, modified 2010]