EC 3.1.8.2 - Diisopropyl-fluorophosphatase

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IntEnz Enzyme Nomenclature
EC 3.1.8.2

Names

Accepted name:
diisopropyl-fluorophosphatase
Other names:
DFPase
OPA anhydrase [ambiguous]
dialkylfluorophosphatase
diisopropyl phosphorofluoridate hydrolase
diisopropylfluorophosphonate dehalogenase
diisopropylphosphofluoridase
isopropylphosphorofluoridase
organophosphate acid anhydrase
organophosphorus acid anhydrolase
somanase
tabunase
OPAA
Systematic name:
diisopropyl-fluorophosphate fluorohydrolase

Reaction

Cofactor

Comments:

Acts on phosphorus anhydride bonds (such as phosphorus-halide and phosphorus-cyanide) in organophosphorus compounds (including 'nerve gases'). Inhibited by chelating agents; requires divalent cations. Related to EC 3.1.8.1 aryldialkylphosphatase. Previously listed as EC 3.8.2.1.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047862
CAS Registry Number: 9032-18-2
UniProtKB/Swiss-Prot:

References

  1. Augustinsson, K.-B. and Heimburger, G.
    Enzymatic hydrolysis of organophosphorus compounds. I. Occurrence of enzymes hydrolysing dimethyl-amido-ethoxy-phosphoryl cyanide (Tabun).
    Acta Chem. Scand. 8 : 753-761 (1954).
  2. Augustinsson, K.-B. and Heimburger, G.
    Enzymatic hydrolysis of organophosphorus compounds. II. Analysis of reaction products in experiments with Tabun and some properties of blood plasma tabunase.
    Acta Chem. Scand. 8 : 762-767 (1954).
  3. Augustinsson, K.-B. and Heimburger, G.
    Enzymatic hydrolysis of organophosphorus compounds. IV. Specificity studies.
    Acta Chem. Scand. 8 : 1533-1541 (1954).
  4. Cohen, J.A. and Warringa, M.G.P.J.
    Purification and properties of dialkylfluorophosphatase.
    Biochim. Biophys. Acta 26 : 29-39 (1957).
  5. Mounter, L.A.
    Enzymic hydrolysis of organophosphorus compounds.
    In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes , 2nd ed. vol. 4 , Academic Press , New York , 1960 , 541-550
  6. In: Reiner, E., Aldridge, W.N. and Hoskin, C.G. (Eds.) Enzymes Hydrolysing Organophosphorus Compounds , Ellis Horwood Ltd. , Chichester, UK , 1989

[EC 3.1.8.2 created 1961 as EC 3.8.2.1, transferred 1992 to EC 3.1.8.2]